利胆化瘀片镇痛抗炎作用的实验研究  

Analgesic and anti-inflammatory effect of Lidan Huayu tablet

作　　者：杨琼[1] 陆付耳[1] 徐丽君[1] 王开富[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院中西医结合研究所,湖北武汉430030

出　　处：《中国中西医结合消化杂志》2006年第1期17-20,共4页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：湖北省武汉市科技局资助项目(2002600513415)

摘　　要：[目的]观察利胆化瘀片的镇痛抗炎作用。[方法]以阿司匹林为对照药物,观察利胆化瘀片对小鼠热刺激和化学刺激所致疼痛的影响;采用二甲苯、冰醋酸等致炎剂,观察利胆化瘀片对小鼠耳廓肿胀及血管通透性的影响。[结果]利胆化瘀片可明显提高热板致痛的痛阈,维持时间长达4 h以上,且随剂量增加而痛阈值增大;减少小鼠因冰醋酸所致的扭体次数,且随剂量增加而次数减少;明显抑制二甲苯所致的耳廓肿胀;对抗冰醋酸所致的腹腔毛细血管通透性增加。[结论]利胆化瘀片具有明显的镇痛抗炎作用。[Objective] To observe the analgesic and anti-inflammatory effects of Lidan Huayu tablet （LHT）. [Methods] Compared with aspirin, the analgesic effect of LHT on mice were investigated with hot plate method and aceticacid-induced body twist method; Anti-inflammatory actions of LHT and aspirin were observed on the models of xylene-induced auricular swelling, celiac capillary permeability of the blood vessl by acetic-acid in mice. [Results] LHT could increase the pain threshold obviously, and the effect maintained as long as 4 hours upwards, and reduce the frequency of body twist, and with the increase of dosage, the pain threshold was higher and higher; and the number of times of twisting body was lower and lower. LHT could inhibit xylene-induced auricular swelling and body twisting response reaction by acetic acid in mice. [Conclusion]Lidan Huayu tablet possesses strong analgesic and anti-inflammation effects.

关 键 词：镇痛 抗炎 利胆化瘀片 小鼠 

分 类 号：R971[医药卫生—药品]