青银注射液抗病毒药效学研究  

PHARMACODYNAMIC STUDY OF QINGYING INJECTION AGAINST VIRUS

作　　者：冯文宇[1] 肖顺汉[1] 贾文祥[2] 

机构地区：[1]泸州医学院药物研究所,四川泸州646000 [2]华西医科大学微生物学教研室

出　　处：《泸州医学院学报》2006年第1期1-5,共5页Journal of Luzhou Medical College

基　　金：国家九五重点科技攻关项目(9690105020)

摘　　要：目的:了解青银注射液对常见致病病毒的抑制作用,为临床用药提供理论依据。方法:体外试验,采用组织细胞培养法,观察药物对柯萨奇(CVB3)、疱疹病毒(HSV-Ⅱ)的抑制作用。体内试验,分别用CVB3、HSV-Ⅱ感染小鼠,经腹腔或静脉注射给药,观察小鼠存活天数,评价药物抗病毒作用。结果:体外试验,本品浓度105μg.ml-1以上,对CVB3、HSV-Ⅱ均有抑制作用;体内试验,本品对感染了HSV-Ⅱ的小鼠,4个给药剂量组小鼠存活天数均比阴性对照组明显延长(P<0.01),具有较好的量效关系。结论:青银注射液对疱疹病毒的抑制作用强,而对柯萨奇病毒的抑制作用稍弱。Objective： To investigate the inhibition of Qingying injection on common viruses. Methods： In vitro test ： the inhibition on CVB3 and HSV - Ⅱ was observed through cell cultivation method. In vivo test ： mice were infected by CVB3 and HSV - Ⅱ respectively. Qingying injection was administered into their abdominal cavity and vein. The survival time （days） was observed to estimate the anti viral effect of the drug. Results： The in vitro test showed that the drug with a concentration more than 105μg·ml^-1 has inhibitive effect on CVB3 or HSV - Ⅱ . The in vivo test showed that all the dosage groups survived for more days than the control group, which exhibits a good dosage - effect relationship. Conclusion： Qingying injection has strong inhibition on HSV - Ⅱ . It is slightly weaker on CVB3, though.

关 键 词：青银注射液 抗病毒 药效学试验 

分 类 号：R96[医药卫生—药理学]