抗骨增生胶囊与葡立胶囊联用对兔颈椎间盘退变的影响  

An experimental study on the degenerated cervical intervertebral discs with Chinese and western medicine

作　　者：赵晓勇[1] 苏江宁[1] 孙喜龙[1] 李旭明[1] 刘福成[1] 刘越[1] 王海涛 

机构地区：[1]河北省人民医院骨科,石家庄050051 [2]石家庄市第三人民医院骨科

出　　处：《中国康复医学杂志》2005年第12期894-896,F0005,共4页Chinese Journal of Rehabilitation Medicine

基　　金：河北省科技厅科技攻关课题(04276187)

摘　　要：目的:了解家兔退变颈椎间盘内细胞因子、蛋白多糖及软骨终板变化情况,观察抗骨增生胶囊与葡立胶囊联合应用对其产生的影响。方法:新西兰大白兔随机分为5组:正常对照组、模型浅层组、模型全层组、药物治疗浅层组、药物治疗全层组,每组10只。通过切除家兔颈背部浅层、全层肌肉,造成颈动力失衡,诱导颈椎间盘退变,建立颈椎退变模型,给予抗骨增生胶囊与葡立胶囊联用冶疗1个月,测定退变颈椎间盘中细胞因子、蛋白多糖、软骨终板变化。结果:模型组与正常对照组相比较,颈椎间盘中IL-1α(P<0.01)、TNFα(P<0.05)含量均明显升高,颈椎软骨终板钙化层明显增厚(P<0.01),蛋白多糖明显降低(P<0.05),中西药冶疗组IL-1α(P<0.05)、TNFα(P<0.05)含量明显降低、蛋白多糖明显升高(P<0.05),软骨终板钙化有明显抑制(P<0.05)。结论:抗骨增生胶囊与葡立胶囊联合应用对退变颈椎间盘多种细胞因子和炎症介质以及软骨终板钙化有明显的抑制作用,可明显恢复颈椎间盘蛋白多糖含量。Objective：To studv the effect of Chinese and western medicine on the change of the contents of cytnkine,prnteoglyean and the thickness of the cartilage end-plate in rabbits＇ degenerated cervical intervertebral discs. Method：By removing superfMal and whole layer dorsal neck muscles, to establish the model of degenerated cervical intervertebral discs in rabbits and applied to examine the contents of cytokine,proteoglyean and the thickness of cartilage end-plate under the therapy of Chinese and western medicine for a month.Result：Compared with control group of normal ralbbits,the conteuts of interleukin-1α（IL-1α）,tumor necrosis factor α（TNFα） and the thickness of cartilage end-plate increased siguificantly while the contents of proteoglycan decreased markedly in the model group. After Chinese and western medicine treatment, the contents of IL-1α,TNFα decreased while the contents of protenglycan was significantly inhibiting on the calification of cartilage end-plate.Conclusion：Anti-hyperosteogeny capsule in combination with glueosemine hydrochloride capsule can inhibit inflammatory reaction and the thickening of cartilage end-plate,relieve cvtokine products and enhance the contents of proteoglycan.

关 键 词：椎间盘 退变 细胞因子 蛋白多糖 软骨终板 抗骨增生胶囊 葡立胶囊 

分 类 号：R285[医药卫生—中药学]