4例着色干皮病伴发鳞状细胞癌临床病理分析  

Squamous Cell Carcinoma in Xeroderma Pigmentosum:A Clinicopathologic Study of 4 Cases

作　　者：李涛[1] 刘喜福[1] 于艳[1] 王晓丽[1] 

机构地区：[1]吉林大学第一临床医院皮肤科,130021

出　　处：《中国妇幼保健》2006年第3期402-403,共2页Maternal and Child Health Care of China

摘　　要：目的：探讨着色干皮病（xeroderma pigmentosum，XP）伴发鳞状细胞癌（squamous cell careinoma，SCC）的临床病理特点。方法：采用组织病理学方法对1993年～2004年间收集的XP伴发SCC患者进行分析。结果：4例中，男性1例，女性3例。发病年龄最小1岁，最大4岁，平均2．5岁。并发肿瘤年龄，最小7岁，最大18岁，平均12．8岁。其中有明确近亲婚配者2例（50％）。4例患者临床症状及病理结果均典型。结论：XP为常染色体隐性遗传性皮肤病，是一种癌前病变，以早年并发恶性肿瘤为其特征，其中以鳞状细胞癌和基底细胞癌最为常见。与皮肤损害和紫外线损伤程度密切相关。Objective： To investigate clinicpathologic features SCC in XP. Methods： Uesd HE to study 4 cases of our own department which were collected from 1993 to 2004. Results： In all four cases , one is male , three are female. Among these patients, a minimum one of age having illness coming on is 1 years old, the oldest one is 4 years old, average 2. 5 years old. The youngest one while erupting the tumor simultaneously is 7 years old, the oldest one isl8 years old, average 12. 5 years old. Among them there are two persons whose parents have history of consanguineous mating. All 4 cases have typical clinicpathologic feature. Conclusion： XP is a kind of autosomal and recessive inherited dermatologic disease, and a pathological change before a kind of cancer, regarding erupting the malignant tumor simultaneously in early years as its characteristic, among them the SCC and basal cell carcinoma are the most common. The skin lesion is closely related with the degree of damage that the ultraviolet ray causes.

关 键 词：着色干皮病 鳞状细胞癌 肿瘤 

分 类 号：R757.58[医药卫生—皮肤病学与性病学]