天葵化石汤提取液对尿结石矿物草酸钙形成的影响  

Effect of Aqueous Extract from Tiankui Soup on Calcium Oxalate Crystallization

作　　者：邓芳[1] 胡鹏[1] 欧阳健明[1] 颜文斌[2] 彭武和 

机构地区：[1]暨南大学生物矿化与结石病防治研究所,广东广州510632 [2]吉首大学化学化工学院,湖南吉首416000 [3]湖南省湘西自治州民族中医院,湖南吉首416000

出　　处：《中国药业》2006年第2期25-27,共3页China Pharmaceuticals

基　　金：国家自然科学基金(20471024);国家自然科学基金重点项目(20031010);教育部留学基金(教外司[2005]55号)。

摘　　要：目的:研究土家族药物天葵化石汤治疗尿石症的化学基础。方法:采用X射线衍射法(XRD)和傅立叶红外光谱(FT-IR)法研究了天葵化石汤提取液对尿石晶体草酸钙(CaOxa)结晶的影响。结果:当天葵化石汤提取液加入量小于5．0 mL(相当于生药1．5 g)时,与空白试验结果相近,主要形成一水草酸钙(COM);随着提取液加入量分别增加至8．0,15．0 mL,CaOxa晶相发生了明显的变化,分别形成了约 73％,100％的二水草酸钙(COD)。结论:该结果在理论上支持临床使用天葵化石汤作为防治泌尿系结石的有效药物。Objective： To study the effect of aqueous extract from Tiankui soup, a Chinese traditional herb from Tujiazu. Methods： The phase compositions af calcium oxalate（CaOxa）were investigated in vitro by means of X- ray powder diffraetion（XRD）and Fourier transform infrared（FT-IR） spectroscopy. The chemical basis of Tiankui soup on curing urinary stone was discussed from the points of chemical complexation and crystal phases of calcium oxalate. Results： When the Tiankui extract was 5.0 mL（corresponding to 1.5 g crude drug）, only COM was precipitated. When the amount of extract increased to 8.0 mL and 15, 0 mL, respectively, about 73% and 100% of the COD crystals were induced, Conclusion： This result supports Tiankui soup may be usd to treat and prevent urinary stones in theory, and may give reference and clue to find new Chinese traditional medicine.

关 键 词：尿结石 草酸钙 中草药 天葵化石汤 

分 类 号：R691.4[医药卫生—泌尿科学] O614[医药卫生—外科学]