健康志愿者口服冠心Ⅱ号煎剂后血清中药物化学成分变化研究  

Serum Pharmacochemistry Changes of Guan Xin Ⅱ Oral Decoction in Healthy Volunteers

作　　者：甘洪全[1] 梅其炳[1] 王雁梅[2] 黄熙[3] 

机构地区：[1]第四军医大学药学系药理学教研室,西安市710032 [2]第四军医大学唐都医院中医科,西安市710038 [3]第四军医大学西京医院中医药研究中心,西安市710033

出　　处：《中国药房》2006年第3期173-177,共5页China Pharmacy

基　　金：国家自然科学基金资助项目(30070912)

摘　　要：目的考察冠心Ⅱ号煎剂口服后化学成分在人血清中的存在状况。方法用3种预处理方法和2种高效液相色谱条件对健康人服用冠心Ⅱ号煎剂后含药血清进行指纹图谱分析,并与煎剂进行比较。结果煎剂、含药血清中的差异色谱峰数目分别不超过30个、10个,后者未检测到丹参素、原儿茶醛、川芎嗪和芍药苷。结论复方制剂中吸收入血的可测化学成分数目有限,其进入体内的化学成分可能“数目相对有限”;口服复方制剂后,原有的部分化学成分可能不以原形存在于血中。OBJECTIVE： To study the presence of the chemical compositions of Guan Xin Ⅱ （GXEH） oral decoction in human serum. METHODS： The analysis of finger prints of the medicated serum sample obtained from the volunteers treated with GXEH decoction was conducted with 3 different pretreaunent procedures and 2 different HPLC methods, and which were compared with decoction. RESULTS： The numbers of the discrepant chromatographic peaks detected from the decoction and the medicated serum were respectively less than 30 and 10,danshensu, protocatechuic aldehyde, ligustrazine,paeoniflorin were failed to be traced in the latter. CONCLUSION：The numbers of chemical compositions of the compound preparation that can be traced in serum were limited and the active components that entered into body may be relatively limited in numbers. After oral administration of compound preparation, a part of chemical compositions of which may not presented as its original form in serum.

关 键 词：中药复方 冠心Ⅱ号 煎剂 血清药物化学 高效液相指纹图谱 

分 类 号：R283[医药卫生—中药学] R284.1[医药卫生—中医学]