肾移植术后服用环孢素A2h血药浓度峰值监测及治疗窗浓度探讨  

Monitoring of Peak Blood Concentration in Renal Transplant Recipients 2h after Oral Administration of Cyclosporine A and Study on Therapeutic Window Concentration

作　　者：王守春[1] 韩丽萍[2] 司凯英[1] 栾杰[1] 

机构地区：[1]黑龙江大庆龙南医院药剂科,大庆市163453 [2]广州军区广州总医院,广州市510010

出　　处：《中国药房》2006年第3期199-201,共3页China Pharmacy

摘　　要：目的探讨肾移植术后国内患者服用环孢素A(CsA)2h血药浓度峰值在不同时期的监测范围。方法用荧光偏振免疫法(FPIA)同时测定92例肾移植受者CsA谷浓度(C0)和服药2h后峰浓度(C2),并观察排斥反应的发生及肝、肾毒性反应。结果肾移植术后CsA C2在不同时期监测范围建议0mo^1mo为1000~1300μg/L,2mo^3mo为950~1250μg/L,4mo^6mo为900~1100μg/L,7mo^12mo为750~1000μg/L,12mo以上为600~800μg/L。结论在上述治疗窗浓度范围,CsA既能达到满意的免疫抑制效果,又能减少排斥反应和肝、肾毒性的发生。OBJECTIVE： To study the therapeutic window of peak blood concentration at different time in domestic renal transplant recipients 2h after administration with cyclosporine A （CsA） . METHODS： The valley bottom levels （C0） and the peak levels （C2） were determined simultaneously by fluorescence polarization immunoassay （FPIA） in 92 patients 2h after oral administration with CsA, the rejection and the hepatic and renal drug toxieities were observed. RESULTS： The recommended therapeutic window concentration of CsA（C2） in Chinese renal transplant recipients was 1 000-1300μg/L within the first month, 950-1250μg/L within the second to third month, 900-1100μg/L within the fourth to sixth month, 750-1000μg/L within the seventh to twelfth month, 600-800μg/L from the twelfth month after renal transplantation. CONCLUSION. Within the above therapeutic window concentration range, CsA is of ideal immuno - suppressive action meanwhile it can less rejection and minimize the hepatic and renal drug toxicities,

关 键 词：肾移植 环孢素A 血药浓度监测 治疗窗 

分 类 号：R979.5[医药卫生—药品]