卡托普利三联小剂量对老年高血压左室肥厚及左室舒张功能的影响  

Efficacy of low-dose captopril triple therapy for left ventricular hypertrophy and left ventricular diastolic function in aged patients with essential hypertension

作　　者：袁章顺[1] 简丽华[1] 许燕山[1] 袁克[1] 肖振军[2] 

机构地区：[1]怀化医专附属医院心内科,湖南怀化418000 [2]中南大学湘雅医院老干科,湖南长沙410008

出　　处：《中国现代医学杂志》2006年第3期434-437,共4页China Journal of Modern Medicine

摘　　要：目的探讨卡托普利三联小剂量对老年轻、中度原发性高血压(EH)合并左室肥厚(LVH)及左室舒张功能不全的疗效及安全性。方法72例老年轻、中度EH合并LVH及其舒张功能不全的患者,随机分为三联小剂量组:给予卡托普利25mg/d,氢氯噻嗪12.5mg/d,氨氯地平2.5￣5.0mg/d,晨顿服;二联常规剂量组:给予卡托普利50mg/d,氢氯噻嗪25mg/d,晨顿服。疗程均为半年,均于药物治疗前、后监测血压、LVH及左室舒张功能变化。结果三联小剂量组在降压疗效(94.44%)、逆转LVH和改善左室舒张功能的各项指标,均明显优于二联常规剂量组(P<0.05)。结论两组均可降低老年EH,逆转LVH和改善左室舒张功能,且小剂量的三药联用效果大于双倍剂量的二药联用。[Objective] To find out the efficacy and safety of low-dose captopril triple therapy for left ventricular hypertrophy and left ventricular diastolic function in aged patients with mild or middle type essential hypertension. [Methods] 72 aged patients with mild or middle type essential hypertension and left ventficular hypertrophy and left ventricular diastolic function were divided into two groups randomly, the low-does captopril triple therapy group （I） and the two drugs combination group （II）： group I was given captopril 25 mg, hydrochlorothiazide 12.5 mg and amlodipine 2.5-5.0 mg per day in the morning, group II was given eaptopril 50 mg and hydrochlorothiazide 25 mg per day in the morning. The course of treatment was half a year. The indexes of the observation included the variety of blood pressure, left ventricular hypertrophy and left ventricular diastolic function after six months treatment in both groups. [Result] It was found that the efficacy of group I was significantly better than group 1I in decreasing the blood pressure （94.44%） and reversing the left ventfcular hypertrophy and improving left ventricular diastolic function （P 〈0.05）. [Conclusion] Both of the treatments can decrease the blood pressure and reverse the left ven- trlcular hypertrophy and improve left ventricular diastolic function. But the efficacy of the low-does captopril triple therapy group is much better than the two drugs combination group.

关 键 词：高血压:老年人 左室肥厚 左室舒张功能 卡托普利 治疗 

分 类 号：R544.1[医药卫生—心血管疾病]