戊型肝炎病毒Ⅳ型中国恒河猴动物模型的建立  

China Rhesus model of HEV gene type-IV infection

作　　者：杨志国[1] 许家璋[1] 鞠九龙[1] 许远红[1] 邱红[1] 乐美兆[1] 孟继鸿[2] 

机构地区：[1]中国人民解放军第81医院肝病研究所,南京210002 [2]东南大学基础医学院

出　　处：《江苏医药》2006年第2期147-148,共2页Jiangsu Medical Journal

摘　　要：目的研究中国恒河猴是否是戊型肝炎病毒(HEV)Ⅳ型的敏感动物模型。方法用Ⅳ型HEV RNA阳性的人粪便提取液感染2只中国恒河猴,动态观察动物感染前后ALT和肝组织学改变及血清、粪便HEV RNA。结果2只恒河猴于感染HEVⅣ型后第5周出现血清ALT升高,持续6周恢复正常;肝组织出现急性肝损伤样改变;感染3周于血清中检出HEV RNA,分别于第32天和第40天粪便中检出HEV RNA。结论中国恒河猴是HEVⅣ型的敏感动物模型。Objective To establish the China Rhesus model of HEV gene type-Ⅳ infection. Methods The changes of sera biochemistry and liver histopathology were observed synchronously. The dynamic changes of HEV RNA in feces, sera of experimentally infected Rhesus monkeys with HEV gene type-Ⅳ were observed. Results Elevated ALT and AST were both observed in the two experimental animals 5 weeks after inoculation,which lasted for 6 weeks. HEV RNA became positive in sera 3 weeks after infection, and detected in feces on the 32nd day and 40th day after infection respectively. Liver biopsy showed acute histopathological changes. Conclusion China Rhesus monkey was a good experimental animal model of HEV gene type-Ⅳ.

关 键 词：戊型肝炎病毒 动物模型 戊型肝炎病毒Ⅳ型 敏感动物模型 恒河猴 中国 ALT升高 动物感染 HEV 组织学改变 

分 类 号：R512.6[医药卫生—内科学]