替硝唑体内抗厌氧菌感染作用的研究  

IN VIVO EFFECT OF TINIDAZOLE AGAINST ANAEROBIC BACTERIA

作　　者：孙延波[1] 王云[1] 关显智[1] 李淑华[1] 

机构地区：[1]白求恩医科大学微生物学教研室,长春医学高等专科学校

出　　处：《中国微生态学杂志》1996年第2期14-16,共3页Chinese Journal of Microecology

摘　　要：本项研究观察了替硝唑对类杆菌，经腹腔感染小鼠的体内保护作用。结果显示替硝唑对脆弱类杆菌和产黑色素类杆菌感染的小鼠，均具有良好的保护作用，两株菌感染的半数有效剂量（ＥＤ５０）分别为１１．１５ｍｇ／ｋｇ和１３．０４ｍｇ／ｋｇ。与甲硝唑相比，两者无显著性差异。In vivo effect of Tinidazole against Bacteroids was studied through intra-abdominal infection.The results showed that Tinidazole was very effective to the infections of B.fragilis and B.melaninogenicus in mice.The ED50 of Tinidazole against infections with B.fragilis and B.melaninogenicus was 11.15mg/kg and 13.04mg/kg,respectively.In comparision with Metronidazole,there is no difference between them.

关 键 词：替硝唑 抗感染药 药理学 

分 类 号：R978[医药卫生—药品]