谷胱甘肽治疗中度妊高征对机体抗氧化系统及新生儿窒息影响的研究  

A study on the role of GSH in the treatment with pregnancy induced hypertension (PIH) to antioxidants system of the body and newborn asphyxia rate.

作　　者：李颖[1] 陈琪玮[2] 

机构地区：[1]沈阳医学院沈洲医院妇产科,110002 [2]沈阳医学院沈洲医院 围产室,110002

出　　处：《中国优生与遗传杂志》2006年第2期40-41,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨低分子抗氧化剂谷胱甘肽在中度妊高征治疗中的作用。方法检测实验组与对照组中度妊高征各 30例脐血中超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽(GSH)、维生素E、维生素C、5项指标,并观察新生儿窒息发生率,进行统计分析。结果治疗组血中MDA水平下降(P<0．01),而GSH、VE、VC(P<0．01)上升,SOD无变化(P>0．05)。结论低分子抗氧化剂谷胱甘肽与维生素E、维生素C联合应用可减少中度妊高征时的自由基损伤,降低了新生儿窒息的发生率。Objective： To evaluate the role of hypermolecule antioxidants compound - GSH in the treatment with PIH. Methods ： The level of serum SOD, MDA, GSH, VE, Vc, in 60 patients with PIH were determined. Results： In experimental group the serum level of MDA was decreased （P〈0.01） and the level ofGSH , VE and VC was increased （P〈0.01）. SOD was not changed （P 〉0.05）. Conclusion： Hypermolecule antioxidants compound - GSH can decrease Free Radicals damage in PIH and newborn asphyxia rate.

关 键 词：谷胱甘肽 妊高征 新生儿窒息率 抗氧化系统 

分 类 号：R714.246[医药卫生—妇产科学] R722.12[医药卫生—临床医学]