蓖麻碱的生物活性研究与应用开发前景  

Biological activity of ricinine and outlook of its applied development

作　　者：刘骁[1] 李端[1] 

机构地区：[1]复旦大学药学院药理学教研室,上海200032

出　　处：《中国药理学与毒理学杂志》2006年第1期76-78,共3页Chinese Journal of Pharmacology and Toxicology

摘　　要：蓖麻碱是蓖麻中的主要毒素之一,具有一定的生物活性。在杀虫方面,对天幕毛虫、桃蚜和小菜蛾等3种害虫有不同程度的杀灭作用;在药理方面,蓖麻碱具有一定的肝保护作用和中枢神经兴奋作用,低剂量时具有改善记忆的效果,较大剂量时可作为工具药,用于制备癫痫动物模型来筛选抗惊厥药。Ricinine is one of main toxic alkaloid in castor bean （Ricinus communis L. ）. Ricinine has some insecticidal effects on the three insect pests and a hepatoprotective activity. Furthermore, ricinine showed some typical central nervous system stimulant effects when admlnistered to mice. At lower doses, ricinine has memory-improving effects. When administered to mice at large doses, ricinine, as a tool drug, may induce seizures. The signs of intoxication caused by ricinine can be used as chemical model of epilepsy in the screening of anticonvulsant drugs.

关 键 词：生物碱类 蓖麻属 杀虫药 植物 惊厥 

分 类 号：R284[医药卫生—中药学]