经导管封堵室间隔缺损对QT离散度的影响  

Effects of transcatheter closure on QT dispersion of patients with ventricular septal defect

作　　者：张志辉[1] 宋治远[1] 孙玉锦[1] 庄国强[1] 史光鉴[1] 陈莉[1] 

机构地区：[1]第三军医大学西南医院心血管内科重庆市介入心脏病学研究所,重庆400038

出　　处：《重庆医学》2006年第3期199-200,共2页Chongqing medicine

基　　金：西南医院临床研究专项基金资助项目(SW2004017)

摘　　要：目的通过观察经导管封堵室间隔缺损(VSD)前后QT离散度(QTd)的变化,探讨VSD封堵术对QTd的影响及意义。方法选在我院接受经导管封堵治疗的72例VSD患者为研究对象,按VSD封堵器大小分为两组,Ⅰ组46例(封堵器<10mm)、Ⅱ组26例(封堵器≥10mm)。分别于术前1d、术后4d同步记录12导联心电图,由电脑自动测算R-R间期、QT间期、QTc间期及QTd。另取12例健康正常人为对照组。结果72例VSD患者术后QTd较对照组明显延长;分组分析发现,虽然Ⅰ、Ⅱ组封堵术后QTd均较对照组明显延长,但以Ⅱ组患者延长更加明显,且此组患者术前QTd即较对照组明显延长。结论VSD经导管封堵术后QTd较对照组明显延长,但其动态演变及临床意义有待于进一步研究。Objective To discuss the change and significance of QT dispersion （QTd） before and after transcatheter closure in patients with ventricular septal defect （VSD）. Methods Seventy two patients with VSD were divided into 2 groups according to di ameter of VSD occludcr： 46 cases in group Ⅰ （occluder diameter 〈10mm）and 26 cases in group Ⅱ （occluder diameter ≥10mm）. Twelve leads ECG record were synchronously taken at ld before and 4d after transcatheter closure. R-R interval, QT interval and QTd were automatically analyzed by computer. Twelve cases of healthy person were acted as control group. Results Compared with healthy control, QTd of post-closure prolonged in Seventy two patients with VSD （group Ⅰand group Ⅱ ）, but more significantly in Ⅱ group. QTd of pre-closure in all VSD patients （group Ⅰ and group Ⅱ ） had no difference from that of control, but significantly prolonged QTd was only found in group Ⅱbefore closure. Conclusion After transcatheter closure of VSD, QTd prolonged significantly compared to control. The dynamic change and clinical effects should be further studied.

关 键 词：室间隔缺损 经导管治疗 QT离散度 先天性心脏病 

分 类 号：R541.1[医药卫生—心血管疾病] R815[医药卫生—内科学]