环孢素A肾中毒时大鼠尿中前列腺素的变化  

THE CHANGE OF URINARY PROSTAGLANDIN CONTENTS IN RATS WITH NEPHROTOXICITY INDUCED BY CYCLOSPORIN E A

作　　者：李民[1] 李俊卿[1] 赵月春[1] 

机构地区：[1]河南医科大学第二附属医院泌尿外科,河南医科大学第二附属医院检验科

出　　处：《河南医学研究》1996年第3期236-239,共4页Henan Medical Research

摘　　要：该实验探讨了环孢素Ａ（ＣｓＡ）肾中毒与肾脏血栓素Ａ２（ＴＸＡ＿２）、前列环素（ＰＧＩ＿２）的关系。实验中将ＳＤ雄性大鼠２０只随机分为二组，Ｉ组为正常对照组；Ⅱ组为ＣｓＡ中毒组。于实验前后分别检测大鼠的肾功能、尿酶以及尿中血栓素Ｂ＿２（ＴＸＢ＿２）、６－酮－前列腺素Ｆ１ａ（６－ｋｅｔｏ－ｐＧＦ１ａ）等指标，最后进行肾脏光镜检查。结果发现，ＣｓＡ中毒组大鼠尿中的ＴＸＢ＿２显著升高，而尿中６－ｋｅｔｏ－ｐＧＦ１ａ稍低于正常对照组，ＴＸＢ＿２／６－ｋｅｔｏ－ｐＧＦ１ａ比值明显升高。实验证实，中毒剂量的ＣｓＡ引起肾脏ＴＸＡ＿２／ＰＧＩ＿２平衡常数明显升高。This study is designed to investigate effect of Cyclosporine A(CsA)nephro-toxicity on urinary thromboxane A2 and prostacyclin,Male Sprague-Dawley rats were dividedinto two groups. Group I is as control;group Ⅱ,rats received a daily oral dose of CsA(50mg/kg)by gavage for seven days,Before and on day 7 of treatment,rat renal function,urinary enzyme and urinary thromboxane B2(TXB2)and 6-keto-prostaglandin F1a(6-keto-PGF1a)were measured.On day 7,kidneys were examined under light lnicroscope.The resultsindicated that CsA produced an acute impairment of renal function,and concomitantly in-creased the ratio of urinarv TXB2/6-keto-pGF1a

关 键 词：环孢素A 肾中毒 前列环素 

分 类 号：R692.902[医药卫生—泌尿科学] R979.5[医药卫生—外科学]