N端脑钠肽前体在心力衰竭诊断中的价值及其与心功能的关系  

Serum Nterminal pro-brain natriuretic peptide :Value and correlation in the diagnosis of heart failure and function

作　　者：张锐[1] 韦建瑞[1] 张文超[1] 

机构地区：[1]暨南大学医学院第四附属医院广州市红十字会医院心血管内科,广东广州510220

出　　处：《皖南医学院学报》2006年第1期29-31,共3页Journal of Wannan Medical College

基　　金：广州市医药卫生科技基金项目(2003012)

摘　　要：目的研究心力衰竭患者血中N端脑钠肽前体(NT-proBNP)水平与心力衰竭及心功能的关系。方法采用电化学法(ECLIA)测定87例心力衰竭患者和11例正常人血清NT-proBNP水平,用心脏彩色多普勒诊断仪测定其左室舒张末径(LVDd)、左室射血分数(LVEF)。结果心力衰竭患者血中BNP水平明显高于正常对照组,并随着心功能纽约分级(NYHA)程度的加重而显著增加,与左室舒张末径(LVDd)呈正相关(r=0.40,P<0.01),与左室射血分数(LVEF)呈负相关(r=-0.62.,P<0.01)。结论NT-proBNP水平可以作为诊断心力衰竭的一个很好的指标,且心力衰竭患者血中的NT-proBNP水平随着心功能的恶化而增加,能较好地反映左室的功能。Objective To study the correlation in level of serum N terminal pro-brain natriuretic peptide,heart failure and function. Methods The level of serum N terminal pro-brain natriuretic peptide from 87 patients with heart failure and 11 healthy adults were measured by ECLIA,LVDd and LVEF were examined by colored Doppler echocardiography. Results The level of N terminal pro-brain natriuretic peptide in patients with heart failure was obviously higher than that of the normal and increased with the increment of NYHA classification. The results showed that NT-proBNP was positively related to LVDd（ r = 0.40, P 〈 0.01） but negatively to EF （r = -0.62, P 〈 0.01）. Conclusion The level of NT-proBNP can be an ideal indication in diagnosis of heart failure since it will increase with the degree of severity of heart failure demonstrating the function of the left ventricular.

关 键 词：N端脑钠肽前体 心力衰竭 心脏功能 诊断 

分 类 号：R541.61[医药卫生—心血管疾病]