行卵母细胞单精子显微注射且年龄≥40岁的患者使用促性腺激素释放激素类似物进行控制性超促排卵治疗短期或长期方案的比较  

Short versus long gonadotropin-releasing hormone analogue suppression protocols for superovulation in patients ≥ 40 years old undergoing intracytoplasmic sperm injection

作　　者：Sbracia M. Farina A. Poverini R. 张剑萍(译) 

机构地区：[1]Dr. M. Sbracia, Center for Endocrinology and Reproductive Medicine, Via Carlo Porta 10, Rome 00153, Italy [2]不详

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第1期34-35,共2页Core Journal in Obstetrics/Gynecology

摘　　要：To determine whether the short or long protocol for controlled ovarian hyperstimulation works better in older patients undergoing IVF. Design: Controlled, randomized study. Setting: A single private IVF center. Patient(s): Two hundred twenty infertile women aged ≥ 40 years undergoing IVF.Intervention(s): At their first IVF cycle, the women were randomized into two stud groups according to a computer-generated number sequence: 110 patients were treated with a long protocol, and the other 110 were treated with a short protocol for controlled ovarian hyperstimulation. Main Outcome Measure(s): Days of stimulation, E2 level at the day of hCG administration, amount of FSH administered, number of oocytes collected, number of embryos obtained, pregnancy rate, implantation rate. Result(s): Patients treated with a long protocol showed a significantly higher number of oocytes retrieved, a higher number of embryos obtained, and a higher pregnancy rate, both for cycle and transfer, compared with the short-protocol patients. The other parameters evaluated did not show any statistically significant differences. Conclusion(s): Our study showed that the long protocol performed better than the short protocol in older women. Our findings demonstrated that flare-up in older women might be detrimental.Objective： To determine whether the short or long protocol for controlled ovarian hyperstimulation works better in older patients undergoing IVF. Design： Controlled, randomized study. Setting： A single private IVF center. Patient（s）： Two hundred twenty infertile women aged ≥ 40 years undergoing IVF. Intervention （s）： At their first IVF cycle, the women were randomized into two study groups according to a computer-generated number sequence： 110 patients were treated with a long protocol, and the other 110 were treated with a short protocol for controlled ovarian hyperstimula- tion. Main Outcome Measure（s）： Days of stimulation, E2 level at the day of hCG administration, amount of FSH administered, number of oocytes collected, number of embryos obtained, pregnancy rate, implantation rate. Result （s）： Patients treated with a long protocol showed a significantly higher number of oocytes retrieved, a higher number of embryos obtained, and a higher pregnancy rate, both for cycle and transfer, compared with the short-protocol patients. The other parameters evaluated did not show any statistically significant differences.

关 键 词：促性腺激素释放激素类似物 超促排卵治疗 卵母细胞单精子显微注射 高龄患者 控制性 年龄 绒毛膜促性腺激素 随机对照研究 方案治疗 细胞数目 

分 类 号：R585[医药卫生—内分泌] R711.6[医药卫生—内科学]