高血压孕妇血浆一氧化氮、内皮素-1和尿一氧化氮及cGMP水平  

Plasma nitric oxide, endothelin- 1 and urinary nitric oxide and cyclic guanosine monophosphate levels in hypertensive pregnant women

作　　者：Baksu B. Davas I. Baksu A. 曾铭华(译) 肖红梅(校) 

机构地区：[1]B. Baksu, B. mah, B. B., D. sitesi A-9 D. : 9, Cengelkoy, Istanbul, Turkey [2]不详

出　　处：《世界核心医学期刊文摘（妇产科学分册）》2006年第1期50-51,共2页Core Journal in Obstetrics/Gynecology

摘　　要：To compare serum levels of nitric oxide (NO) and endothelin- 1 (ET- 1), and urinary concentrations of NO and cyclic guanosine monophosphate (cGMP) between preeclamptic and normotensive pregnant women. Method: Ninety-one preeclamptic (48 mild, 43 severe) and forty healthy normotensive pregnant women above 32 gestational weeks were recruited into study. Chemiluminesence technique was used for measuring plasma and urinary NO levels, and radioimmunoassay was used to determine plasma ET- 1 and urinary cGMP levels. Result: Plasma and urinary NO, and urinary cGMP levels were significantly lower in preeclamptics than in the control group (respectively, p < 0.001, p < 0.001, p < 0.01). Plasma ET- 1 levels were significantly higher in the preeclamptics than in the control group (p < 0.001). There were significant negative correlations between plasmaET- 1, plasma NO and urinary NO and cGMP in all groups. There were positive correlations between plasma NO, urinary NO and cGMP in all groups. Conclusion: The imbalance between NO and ET- 1 may play a significant role in the pathophysiology of preeclampsia.Objective： To compare serum levels of nitric oxide （NO） and endothelin - 1 （ET - 1 ）, and urinary concentrations of NO and cyclic guanosine monophosphate （cGMP） between preeclamptic and normotensive pregnant women. Method： Ninety-one preeclamptic （48 mild, 43 severe） and forty healthy normotensive pregnant women above 32 gestational weeks were recruited into study. Chemiluminesence technique was used for measuring plasma and urinary NO levels, and radioimmunoassay was used to determine plasma ET- 1 and urinary cGMP levels. Result： Plasma and urinary NO, and urinary cGMP levels were significantly lower in preeclamptics than in the control group （respectively, p 〈0.001, p〈0. 001, p〈0. 01） . Hasma ET-1 levels were significantly higher in the preeclamptics than in the control group （p 〈 0. 001 ）. There were significant negative correlations between plasmaET - 1, plasma NO and urinary NO and cGMP in all groups. There were positive correlations between plasma NO, urinary NO and cGMP in all groups. Conclusion： The imbalance between NO and ET- 1 may play a significant role in the pathophysiology of preeclampsia.

关 键 词：内皮素-1(ET-1) 尿NO 正常孕妇 P水平 血浆一氧化氮 高血压 血清一氧化氮(NO) 一氯化氮 放射免疫法测定 先兆子痫 

分 类 号：R446.11[医药卫生—诊断学] R575.2[医药卫生—临床医学]