低温时蛙皮素对IL-1β致热大鼠下丘脑和血浆cAMP含量的影响  

Effects of bombesin on cAMP content of hypothalamus and plasma in IL-1β-induced fever rats under lower temperature

作　　者：张量[1] 佟雷[2] 杨宇[1] 赵书芬[2] 

机构地区：[1]沈阳医学院生理教研室 [2]中国医科大学基础医学院生理教研室

出　　处：《中国临床药理学与治疗学》2005年第12期1354-1357,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：辽宁省自然科学基金资助课题(№972229)

摘　　要：目的以大鼠为实验对象建立发热动物模型,研究4℃时蛙皮素的降温作用及其与cAMP的关系。方法选择SD雄性大鼠,4℃下侧脑室微量注射蛙皮素、白细胞介素-1β,观察大鼠体温变化情况,并测定下丘脑和血浆中cAMP含量。结果在IL-1β诱导发热大鼠中,下丘脑及血浆中cAMP含量与对照组相比升高(P<0.01);蛙皮素可以降低大鼠正常体温,下丘脑cAMP含量与对照组相比亦随之降低(P<0.01);预先侧脑室注射蛙皮素能翻转大鼠IL-1β性发热,且下丘脑cAMP含量与IL-1β组相比明显下降(P<0.01)。结论4℃时蛙皮素能抑制IL-1β发热,其机制有可能是通过抑制cAMP合成或释放实现的。AIM： To study the effects of bombesin on thermoregulation and its relationship with camp content at 4℃. METHODS： Bombesin and IL-1β were microinjected into the lateral ventricles （LV） of male SD rats. Changes in colonic temperature and content of cAMP in hypothalamus and plasma were measured. RESULTS： （1） In the febrile rats induced by i. c.v. injection of IL- 1β, content of cAMP in hypothalamus and plasma increased （ P 〈 0.01 ）. （2） Bombesin could lower normal body temperature in rats. Content of cAMP in hypothalamus was lower than that in the control group （ P 〈 0.01 ）. （3） Fever induced by IL-1β was reversed by pretreatment with bombesin, and content of cAMP in hypothalamus was decreased compared with that in control group （P 〈 0.01）. CONCLUSION： Bombesin can inhibit IL-1β-induced fever at 4 ℃, and the mechanism may be related to the inhibition the synthesis and release of cAMP.

关 键 词：蛙皮素 白细胞介素-1Β CAMP 发热 下丘脑 体温调节 

分 类 号：R965[医药卫生—药理学]