奥美拉唑与其他药物治疗消化性溃疡及出血对照研究Meta分析  

Meta-analysis of effectiveness of omeprazole and other drugs in treatment of active peptic ulcer and bleeding

作　　者：陈永荣[1] 

机构地区：[1]六安市中医院药剂科

出　　处：《中国临床药理学与治疗学》2005年第12期1420-1422,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的:了解奥美拉唑(Omeprazole, Om)与其他药物治疗消化性溃疡及出血疗效的差异.方法:应用Meta分析对9项研究消化性溃疡及出血的效果进行同质性检验和合并效应量的估计.结果:(1)同质性检验:χ2=9.84,自由度8,P>0.05.(2)合并效应量的估计:OR合并95%可信区间为 2.83～6.68.OR合并的检验:χ2=44.4,P＜0.01.结论:奥美拉唑治疗消化性溃疡及出血的疗效优于目前常用药物, Om在治疗消化道溃疡及出血疗效方面较其他已上市药物都要好,且无明显不良反应,值得临床推广.AIM： To explore the difference of efficacy between omeprazole and other drugs in treatment of active peptic ulcer and bleeding. METHODS： The efficacy of omeprazole or other drugs in treatment of active peptic ulcer and bleeding was analyzed by Meta-analysis in homogeneity test and combined test in 9 studies. RESULTS： Homogeneity test showed that the cited studies were homogeneous with X^2 = 9.84, P 〉 0.05; and in combined test, the combined OR = 4.42 and its 95 % confidence interval was in 2.83 - 6.68 （X^2 = 44.4, P 〈 0.01）. CONCLUSION： Omeprazole is a very effective and well-tolerated proton pump inhibitor and it is worthy of being recommended for administration in patients with active peptic ulcer and bleeding.

关 键 词：奥关拉唑 消化性溃疡 META分析 临床试验 比数比 

分 类 号：R969[医药卫生—药理学]