同种异体带瓣管道重建右室流出道的耐久性随访研究  

A follow-up study on durability of valved homograft conduit used in right ventricular outflow tract reconstruction

作　　者：蔡小满[1,2] 刘锦纷[1,2] 张海波[1,2] 

机构地区：[1]上海第二医科大学附属新华医院 [2]上海儿童医学中心心胸外科

出　　处：《中华胸心血管外科杂志》2005年第6期341-343,共3页Chinese Journal of Thoracic and Cardiovascular Surgery

摘　　要：目的探讨深低温保存的同种异体带瓣管道(valved homograft conduit,VHC)在重建小儿右室流出道(right ventricular outflow tract,RVOT)中耐久性情况,及影响其耐久性的危险因素。方法 1989年 11月至2003年7月用VHC重建RVOT,随访65例次临床情况、心电图、X线胸片、心脏超声和心脏MRI。借此了解病儿体内VHC钙化、梗阻和反流情况。用现代统汁方法分析影响VHC耐久性的危险因素。结果 65例次中VHC中位生存时间10．9年,管道生存最长时间12．8年。结论小年龄(≤4岁)、低体重 (≤10 kg)和主动脉VHC是影响VHC耐久性的危险因素。Objective To investigate the durability of the cryopreserved valved homograft conduit （VHC） used in reconstruction the right ventricular outflow tract （RVOT） and its risk factors. Methods 119 cases tmdergoing VHC reconstruction the RVOT in our hospital between November 1989 and July 2003. 65 cases were followed-up, including the clinical examination, electrocardiography, chest radiography, echocardiagraphy, or cardiac MRI for detection of development of homografi calcifications, obstruction and conduit valve regurgitation, and we used the morden statistics method to analyze the factors for the VHCs＇ durability. Results Among 65 cases, the median survival time for the VHCs was 10.9 years. The longest survival lasted for 12.8 years. The homagrafts failure was 15.4%. Conclusion The younger age（ ≤4 y）, smaller weight（ ≤ 10 kg）, aortic homograft are the risk factors for the VHC＇ durability （P 〈 0.05）.

关 键 词：移植 同种 移植物存活 随访研究 心室 同种异体带瓣管道 右室流出道 管道重建 耐久性 危险因素 心脏超声 

分 类 号：R726.5[医药卫生—儿科]