儿童消化性溃疡药物治疗的临床研究  

The clinical trial on the treatment of pediatric peptic ulcer.

作　　者：刘彦琦[1] 赵卫平[2] 苏秉忠[1] 

机构地区：[1]内蒙古医学院附属医院消化内科,内蒙古呼和浩特010058 [2]内蒙古自治区医院神经外科,内蒙古呼和浩特010050

出　　处：《中国儿童保健杂志》2006年第1期29-30,共2页Chinese Journal of Child Health Care

摘　　要：【目的】比较不同方案治疗儿童消化性溃疡(peptic ulcer,PU)的疗效和幽门螺杆菌(helicobacter pylori,Hp)的根除率,并评价根除Hp在儿童PU愈合中的作用。【方法】80例Hp感染伴PU的患儿分两组接受治疗。A组奥美拉唑0.8 mg/(kg.d)顿服,疗程2周;B组胶体枸橼酸铋8 mg/(kg.d),每日分3次口服,疗程2周。上述两组同时加服阿莫西林50 mg/(kg.d)和甲硝唑15 mg/(kg.d),均分为3次口服。【结果】溃疡的愈合率A组91.67%(4 4/4 8),B组7 5.0 0%(2 4/3 2);Hp的根除率A组8 3.3 3%(4 0/4 8),B组5 6.2 5%(1 8/3 2);Hp根除者溃疡愈合率96.56%,未根除者愈合率54.55%,差异有显著性(P<0.01)。【结论】质子泵抑制剂奥美拉唑加两联抗生素组成的三联疗法治疗儿童Hp感染的消化性溃疡具有疗效高的优点,根除Hp可以提高儿童PU的愈合率。[Objectives] To observe the effect of different therapy in the management of peptic ulcer and the eradicative rate Helicobacter pylori. [Methods] 80 patients with pediatric Helicobacter pylori peptic ulcer were divided into 2 groups. Group A was treated with Omeprazole 0. 8mg/（kg · d） for 2 weeks, group 13 with CBS 8 mg/（kg · d） for 2 weeks. Amoxycillin 50 mg/（kg · d） and metronidazol were adrnindstered to all the groups. [Results] 91.67%（44/48） of peptic ulcer in group A,75.00%（24/32） in group B. 83.33%（40/48） of Helicobacter pylori in group A, 56.25%（ 18/ 32 ） in group B were eradicated. 96. 56 % of the peptic ulcer were cured in patients Helicobacter pylori eradicated , while 54.55% in uneradicated. [Conclusion] Proton pump inhibitor（Omeprazole） in combination with antibiotics is showed more efficient therapeutic effect, Helicobacter pylori eradication can improve the pediatric peptic ulcer cure rate.

关 键 词：幽门螺杆菌 儿童 消化性溃疡 药物 

分 类 号：R722.1[医药卫生—儿科]