Boston命名测验在识别轻度认知损害和阿尔茨海默病中的作用  

Boston Naming Test in Chinese Elderly, Patient with Mild Cognitive Impairment and Alzheimer's Dementia

作　　者：郭起浩[1] 洪震[1] 史伟雄[1] 孙一忞[1] 吕传真[1] 

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《中国心理卫生杂志》2006年第2期81-84,共4页Chinese Mental Health Journal

摘　　要：目的观察Boston命名测验(Boston Naming Test,BNT)30项版本在中国的适用状况和对于遗忘型轻度认知损害(aMCI)与阿尔茨海默病(AD)的识别作用。方法应用BNT(中文版)、简明精神状态量表(MMSE)和听觉词语记忆测验等神经心理测验评估100名社区正常老人、38名MCI、34名轻度AD和38名中度AD患者,4组被试的MMSE总分分别为28.4±1.5、26.1±2.6、20.7±1.7和15.6±3.3。结果正常老人的BNT的自发命名得分与年龄、性别和受教育程度显著相关。正常老人组、aMCI组、轻度AD组和中度AD组自发命名得分分别为24.9±3.0、20.9±3.6、18.7±4.0和15.7±4.2分。以BNT自发命名≤22分作为划界分,识别aMCI的敏感性为61%,识别轻度AD的敏感性为79%,识别中度AD的敏感性为95%,特异性均为81%。提示命名、选择命名能力在aMCI和轻中度AD患者中也呈现进行性损害,但比自发命名能力的下降轻得多。结论正常老人的命名能力受到其年龄、性别和教育程度的影响,aMCI和早期AD患者存在命名能力损害。Objective： To investigate applicability for Boston naming test （30 items） （BNT） in Chinese elderly and identify effect for mild cognitive impairment （MCI） and Alzheimerg dementia （AD） using BNT. Methods： 100 normal elderly, 38 amnesic MCI, 34 mild AD and 38 moderate AD were evaluated by neuropsychological tests （ include BNT, mini mental state examination [ MMSE] and auditory verbal memory test, etc） . MMSE total score of 4 groups were 28.4 ± 1.5, 26. 1 ± 2. 6, 20. 7 ± 1.7, and 15. 6 ± 3.3, respectively. Results： Age, sex, level of education were found to be significant factors affecting overall scores of spontaneous naming in normal elderly group. Spontaneous naming score for participants of elementary, high school and college groups were 22. 2 ± 3.3, 25.5 ± 2.5 and 26. 3 ± 1.8, respectively. Scoring of male participants higher than that of females. Spontaneous naming score of 4 groups were 24.9 ±3.0, 20. 9 ±3.6, 18.7 ±4. 0 and 15. 7 ±4. 2, respectively. As cut-off ≤22 score of spontaneous naming of BNT, the sensitivities for MCI, mild AD and moderate AD were 61%, 79% and95% respectively; the specifieities were all around 81%. Selective impairment of unfamiliar items occurred MCI and mild AD and hold of famil- iar item across diagnostic groups. Semantic cue naming and recognition ability by BNT showed there was progressive damage in AD patients, but less than that of spontaneous naming of BNT. Conclusion： The ability of naming is influenced by age, gender and educational level. Patients with MCI or mild AD have impairment in naming.

关 键 词：Boston命名测验 轻度认知损害 病例对照研究 阿尔茨海默病 

分 类 号：G449.1[哲学宗教—心理学]