雌激素受体在人粘液表皮样癌细胞系中的表达  

Expression of estrogen receptor in human salivary mucoepidermoid carcinoma

作　　者：魏红宇[1] 吴军正[1] 王静[1] 温德生[1] 许杰[1] 

机构地区：[1]第四军医大学口腔医学院口腔生物教研室,陕西西安710032

出　　处：《临床口腔医学杂志》2006年第2期90-92,共3页Journal of Clinical Stomatology

摘　　要：目的:测定雌激素受体在人涎腺粘液表皮样癌细胞系Mec-1以及高转移株Mc-3上的表达,为口腔肿瘤临床内分泌治疗提供依据。方法:用免疫细胞化学方法和RT-PCR方法检测雌激素受体在人涎腺粘液表皮样癌细胞上的表达,并对其表达量进行相对定量分析。结果:经免疫细胞化学和RT-PCR方法可检测到ER在人涎腺粘液表皮样癌细胞上有表达,并且Mc3细胞系ER表达强于MEC-1;两种细胞系ER-α表达均略强于ER-β。结论:雌激素有可能通过它的受体对人粘液表皮样癌细胞产生一定的影响。ERα/ERβ比率升高在粘液表皮样癌发生过程中可能起一定作用,ER的表达升高可能与肿瘤转移力有关。Objective： To observe the expression of estergon receptor alpha and beta in human Salivary mucoepidermoid carcinoma line mec-1 and its highly metastatic cells Mc3, and provide experimental basis for internal hormone therapy of oral and maxillaofacial Methed： lmmunocytochemistry and RT-PCR methods were used to observe the expression of estergon recaptors （ ER ） in human salivary mucoepidermoid carcinoma cells Mec 1 and Mc3. Result： ER-α and ER-β mRNA were expressed in human Salivary mucoepidermoid carcimnoma ceils, and the expression of ER in Mc3 was stronger than in Mec-1, the expression of ER-βwas weaker than ER-α. Conclusion：Estregon may affects human Salivary mucoepidermoid carcinoma cells by it receptor path . The ratio-change between ER-α and ER-β may be associate with the development of human Salivary mucoepidiemoid carcinoma. The overexprexsion of ER may be associate with the metastasis of human Salivary mucoepidiemoid carcinoma.

关 键 词：雌激素受体 人粘液表皮样癌细胞 内分泌治疗 转移力 

分 类 号：Q813.1[生物学—生物工程]