克罗米芬兴奋试验预测卵巢储备功能的价值  

Prediction of ovarian reserve using clomiphene citrate challenge test in infertile women

作　　者：易艳红[1] 黄睿[1] 吴敬之[1] 

机构地区：[1]广东省妇幼保健院集爱遗传与不育诊疗中心,广东广州510010

出　　处：《中国实用妇科与产科杂志》2006年第2期115-117,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨克罗米芬兴奋试验(CCT)在不孕妇女中预测卵巢储备功能的作用。方法对2001年1月至2005年2月就诊于广东省妇幼保健院的666例不孕症患者作为研究对象,分为A组(≥35岁)461例为高龄组,B组(<35岁)205例为低龄组,另取156例年龄<35岁、非女方不孕原因者作为对照组,对三组受试者进行CCT。结果CCT异常发生率A组、B组及对照组分别为27.76%、34.14%、2.56%,A组及B组与对照组比较差异均有非常显著性意义(P<0.01)。基础卵泡刺激素(FSH)<10IU/L、雌二醇(E2)<180pmol/L的不孕患者CCT异常发生率分别为17.46%、24.19%,均明显低于FSH≥10IU/L、E2≥180pmol/L患者的64.19%及39.4%(P<0.01)。结论CCT预测卵巢储备功能较基础FSH更敏感,CCT可作为常规了解卵巢储备功能的一项检测方法。Objective To explore the role of clomiphene citrate challenge test （CCT） in evaluating ovarian reserve in infertile women. Method From January 2001 to February 2005, 666 infertile women were enrolled as study group in Guangdong Provincial Woman ＆ Child Health Hospital. They were divided into two subgroups according to patients age, group A （ ≥35 y） and group B （〈35y）. The control group were 156 healthy young （〈35y） female cases. Both groups received CCT. Results The CCT abnormal rates in group A was 27.76%, group B 34. 14%, while it was 2. 56% in control group. The later was significantly lower than those of group A and B （P 〈0.01 ）. The CCT abnormal rate in patients whose basal FSH level lower than 10IU/L or basal E2 level lower than 180pmol/L was 17.46% and 24.19%, which were significantly lower than those patients whose basal FSH level≥ 10IU/L （CCT abnormal rate 64. 19% ）or E2 level ≥ 180pmol/L （39.40%） （P 〈 0.01 ）. Conclusion CCT is more sensitive than basal FSH measurement to predict ovarian reservation. CCT can be chosen as an effective method to predict ovarian reservation.

关 键 词：氯米芬 卵巢 卵泡刺激素 不孕 

分 类 号：R71[医药卫生—妇产科学]