杏丁治疗对糖尿病肾病患者血浆血栓调节蛋白和血管性血友病因子的影响  

Effect of Xingding injection on thrombomodulin and von Willebrand factor in patients with diabetic nephropathy

作　　者：张饰[1] 胡海云[1] 王学玉[1] 丁国华[1] 

机构地区：[1]武汉大学人民医院肾内科,430060

出　　处：《实用医学杂志》2006年第3期283-285,共3页The Journal of Practical Medicine

摘　　要：目的:观察杏丁治疗对糖尿病肾病(D N)患者血浆血栓调节蛋白(TM)和血管性血友病因子(vW F)的影响。方法:60例D N患者,随机分为常规治疗组和杏丁治疗组。所有患者均于治疗前后抽血测TM、vW F、纤维蛋白原(FIB)、活化部分凝血活酶时间(A PTT)及血黏度。结果:杏丁治疗组患者治疗后,TM、vW F、FIB及血浆黏度均较治疗前显著下降(P<0.01),全血黏度下降(P<0.05),A PTT显著延长(P<0.01),且与常规治疗组相比较,差异有显著性(P<0.05)。结论:D N患者体内存在内皮的损伤,高凝倾向。对D N患者早期使用杏丁治疗,可以有效地保护其血管内皮系统,改善其体内的高凝状态,对延缓疾病的进展有着重要意义。Objective To explore the effect of Xingding injection on thrombomodulin（TM） and yon Willebrand factor（vWF） in patients with diabetic nephropathy, Methods Sixty patients with diabetic nephropathy were randomly divided into routine therapy group and Xingding injection group. The TM, vWF, fibrinogen（FIB）, APTr and blood viscosity were measured before and after treatment. Results Compared with routine therapy group, TM, vWF, FIB and blood viscosity were significantly decreased（ P 〈 0.05）, APTT was increased in patients with Xingding injection（ P 〈 0. 01 ） . Conclusions Xingding injection can effectively protect endothelial cell and ameliorate hypercoagulability in diabetic nephropathy patients. Xingding plays an important role in the prevention of diabetic nephropathy progression.

关 键 词：糖尿病肾病 银杏素 血栓调节蛋白 血管性血友病因子 糖尿病肾病患者 血浆血栓调节蛋白 治疗组 杏丁 活化部分凝血活酶时间 肾病(DN) 

分 类 号：R259[医药卫生—中西医结合]