慢性乙型肝炎患者E-选择素A561C基因多态性的研究  

Study of A561C polymorphisms of E-selectin in patients with chronic hepatitis B

作　　者：冯忠军[1] 张淑兰[2] 张金华[1] 

机构地区：[1]河北医科大学第三医院检验科,050051 [2]石家庄市中医院检验科,050051

出　　处：《河北医药》2006年第1期11-12,共2页Hebei Medical Journal

基　　金：石家庄市科技局科技攻关项目(04246223)

摘　　要：目的研究中国河北地区汉族人群E-选择素(E-selectin)A561C基因多态性与慢性乙型肝炎的相关性。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术,检测91例慢性乙型肝炎患者和85名健康对照组的E-selectin基因多态性。结果中国河北地区汉族人群中E-selectin A561C存在AA、AC和CC三种基因型,E-selectin A561C多态性在慢性乙型肝炎组和对照组间的分布差异显著(x2=5．96,P<0．05)。AC+CC基因型患慢性乙型肝炎的风险是AA基因型的2．89倍(OR=2．89, 95％CI:1．20-6．94)。等位基因频率在两组间差异也有显著性(x2=6．14,P<0．05,OR=2．23,95％CI: 1．02-4．85)。结论中国河北地区汉族人群中存在E-selectin A561C位点单核苷酸多态性,其基因多态性与慢性乙型肝炎的感染具有相关性,C等位基因可能是中国河北地区慢性乙型肝炎发病的易感因素之一。Objective To investigate the correlation between E-selectin A561C polymorphisms and chronic hepatitis B.Methods E-selectin A561C polymorphisms were detected by PCR-RFLP in 91 patients with chronic hepatitis B and 85 healthy subjects. Results Three genotypes （AA, AC and CC） of E-selectin A561C polymorphisms were found in the Han people in Hebei Province,There was a significant difference in frequencies of genotype in E-selectin A561C polymorphisms between patients and healthy subjects （x^2 = 5.96, P 〈 0.05）. The relative risk of suffering from chronic hepatitis B in genotype AC ＋ CC was as 2.89 times high as that of AA genotypes （OR = 2.89; 95 % CI：1. 20- 6.94）. Meanwhile there was a significant difference in allele frequency between the two groups （X^2 = 6.14, P 〈0.05,OR=2.23;95% CI：1.02-4.85）.Conclusion E-selectin A561C polymorphismexitsinthe Han people of Hebei province. There is a correlation between E-selectin A561C polymorphisms and chronic hepatitis B infection in the north area of China. Allele C may be one of the predisposing factors of chronic hepatitis B.

关 键 词：慢性乙型肝炎 E-选择素 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病] R512.62[医药卫生—内科学]