固本延衰方对亚急性衰老模型小鼠脾淋巴细胞增殖的影响  

Influence of Guben Yanshuai Recipe on the Spleen Lymphocyte Proliferation of the Rat Model with Subacute Senility

作　　者：王敏[1] 王平[2] 王彦春[1] 洪小平[1] 韩永明[1] 段妍君[1] 邹峰[1] 

机构地区：[1]湖北中医学院基础医学部,湖北武汉430061 [2]广州军区武汉总医院肾内科,湖北武汉430070

出　　处：《湖北中医学院学报》2005年第3期9-10,共2页Journal of Hubei College of Traditional Chinese Medicine

基　　金：湖北省教育厅资助青年课题 2003B00001

摘　　要：目的探讨固本延衰方延缓亚急性衰老模型小鼠衰老的机制。方法将60只小鼠随机分为4组,除正常对照组外均皮下注射D-半乳糖造成衰老模型,并给予不同剂量的固本延衰方治疗,用MTT法测定脾淋巴细胞增殖水平。结果衰老模型组脾淋巴细胞增殖水平明显低于正常对照组(P<0.01),固本延衰方大小剂量组脾淋巴细胞增殖水平均高于衰老模型组(P<0.01),结论固本延衰方可提高衰老机体淋巴细胞增殖活性,从而调节免疫功能延缓衰老。Objective： To research the mechanism Of GubenYanshuai Fang（GBYSF） to postpone the senescence of the subacute aging model mice. Methods= 60 mices be divided into 4 groups and made aging model using D-glucose subcutaneous injection except the control group. After treating with different dosage GBYSF, We detect the spleen lymphocyte proliferation. Results：The level of spleen lymphocyte proliferation in model group is lower than that of control group（P〈0.01）, the level of spleen lymphocyte proliferation in maximum and minimum dosage of GBYSF group are higher than that of model group （ P〈 0. 01） .Conclusion： It implies that GBYSF could postpone aging from improving the level of spleen lymphocyte proliferation then regulating the body＇s immune function.

关 键 词：固本延衰方 D-半乳糖 衰老 脾淋巴细胞增殖 

分 类 号：R285.5[医药卫生—中药学]