阿糖胞苷聚氰基丙烯酸正丁酯纳米粒冻干针剂体外释药特性  

The release characteristics in vitro of cytarabine (Ara-C) poly-alkyl-acyanoacrylate lyophilized nanoparticles for injection

作　　者：余继英[1] 何林[1] 周静[2] 孙世明[1] 蒋学华[2] 

机构地区：[1]四川省人民医院药剂科,成都610072 [2]四川大学华西药学院,成都610041

出　　处：《中国新药杂志》2006年第3期208-210,共3页Chinese Journal of New Drugs

基　　金：四川省卫生厅科学研究基金(000107)

摘　　要：目的:研究阿糖胞苷聚氰基丙烯酸正丁酯纳米粒(Ara-C-PBCA-NP)冻干针剂体外释药特性。方法:采用HPLC法测定不同时间的阿糖胞苷(Ara-C)在释药介质中的累积释放百分率,并用不同的释药方程进行拟合。结果:Ara-c-PBCA-NP冻干针剂中,Ara-C的释药规律可用多种数学模型拟合,以双指数方程拟合为优。Ara-C的体外释药百分率平均为(95．86±1．76)%。结论:Ara-C-PBCA-NP冻干针剂体外释放具有一定的缓释特征。Objective： To study the release behaviors in vitro of cytarabine （Ara-C） poly-alkyl-α-cyanoacrylate lyophilized nanoparticles （ Ara-C-PBCA-NP ） for injection. Methods： The sustained release of Ara-C was determined by HPLC in released medium, and the release behavior was simulated with different equations. Results： The in vitro average release rate of Ara-C-PBCA-NP lyophilization was （95.86 ± 1.76） %. The release behavior was simulated the most in the biexponential equation. Conclusion： The in vitro release of Ara-C-PBCA-NP lyophilization behaves a sustained release.

关 键 词：阿糖胞苷 纳米粒 冻干针剂 体外释药 

分 类 号：R944.9[医药卫生—药剂学] R973.4[医药卫生—药学]