大黄对糖尿病大鼠肾组织非酶促糖基化的影响  

Effect of Rheum officinale on nonenzymatic glycosylation of renal tissue in diabetic rats

作　　者：黄翠玲[1] 李才[1] 邓义斌[1] 王丽娟[1] 张秀云[1] 赵丽艳[1] 

机构地区：[1]白求恩医科大学应用基础医学研究所,白求恩医科大学第三临床医院检验科

出　　处：《中国糖尿病杂志》1996年第2期103-106,共4页Chinese Journal of Diabetes

基　　金：吉林省卫生厅科研基金

摘　　要：研究了大黄醇提物（Ｒ）对糖尿病（ＤＭ）大鼠肾组织非酶促糖基化（糖基化）的影响。结果表明，Ｒ能减轻ＤＭ大鼠肾脏肥大，使肾重／体重值明显下降，降低ＤＭ大鼠血肌酐（Ｓｃｒ）和尿素氮（ＢＵＮ）水平，使ＤＭ大鼠血糖、果糖胺（ＦＳ）和糖化珠蛋白（ＧＧｂ）含量明显下降。Ｒ处理后能明显减少ＤＭ大鼠肾皮质５－羟甲基糠醛（５－ＨＭＦ）释放量和肾小球系膜区硝基四氮唑蓝（ＮＢＴ）染色强度。这些结果提示，大黄对糖尿病肾脏组织糖基化产物的形成有抑制作用。The effect of Rheum officinale alcohol extract(R)on nonenzymatic glycosylation of renal tissue in streptozotocin(STZ)-induced diabetic rats was studied.The results showed that R treatment decreased the renal hypertrophy and kidney weight/body weight ratio in diabetic rats.The levels of serum creatinine(Scr),blood urea nitrogen(BUN),blood glucose,serum fructosamine(FS)and glycosylated globin(GGb)were significantly lowered in R-treated diabetic rats.After administration of R 5-hydroxymethyl furfural(5-HMF) release from renal cortex and intensity of nitroblue tetrazolium(NBT)staining of glomerular mesangial areas in diabetic animals were markedly reduced.These findings suggested that R had an inhibitory role in formation of glycosylated products in diabetic kidney.

关 键 词：大黄 糖尿病 肾组织 非酶促糖基化 中药 药理学 

分 类 号：R282.710.5[医药卫生—中药学] R259.871[医药卫生—中医学]