NIDDM患者微量白蛋白尿与冠心病的关系  

The relationship between microalbuminuria and coronary heart disease in NIDDM

作　　者：施曼珠[1] 张俊清[1] 钱荣立[1] 杨建梅[1] 贾培红[1] 张树彬[1] 欧阳福珍[1] 邓正明[1] 李琼芳[1] 张少石 秦淑珍 康新满 李美莲 李经 胡伟 鲁梅花 

机构地区：[1]北京医科大学第一附属医院内分泌科,北京医科大学第三附属医院内分泌科,北京市建工医院内分泌科,北京市酒仙桥医院内分泌科,北京市朝阳医院内分泌科,北京市宣武医院内分泌科

出　　处：《中国糖尿病杂志》1996年第3期131-134,共4页Chinese Journal of Diabetes

摘　　要：１０９例年龄≤６０岁的ＮＩＤＤＭ患者，其中４０例并有微量白蛋白尿或早期蛋白尿，６９例正常白蛋白尿，分析比较两组心血管疾病危险因素与心脏受损情况，结果发现微量白蛋白尿组与正常白蛋白尿组相比，缺血性心电图异常发生率较高（２５％比１５．９％），超声心动图左室舒张末期内径较大（４．８６±０．５４ｃｍ比４．６９±０．５５ｃｍ，Ｐ＜０．０５），表明微量白蛋白尿组有心脏受损较多的倾向，提示微量白蛋白尿是ＮＩＤＤＭ患者发生缺血性心脏病的危险信号。The heart rate, blood pressure, electrocardiogram(ECG), ultrasonic-cardiogram(UCG), plasma glucose, serum insulin, triglyceride(TG), high density lipoprotein(HDL), cholestrol,glycosylated hemoglobin and urine albumin excretion rate(UAER) were examined in 109 NIDDM patients. Forty of them were found to have microalbuminuria or early proteinuria and 69 were normal with regard to microalbuminuria. The results showed that the patients with microalbuminuria had higher incidence of ischemic ECG abnormality (25%vs 15.9%)and larger left ventricular end-diastolic caliber than those with normal microalbuminuria (4.86±0.54 cm vs 4.69±0.55 cm,P<0.05).These data indicated NIDDM patients with microalbuminuria were apt to have the heart damage, and microalbuminuria might be a dangerous signal of ischemic heart disease in NIDDM.

关 键 词：糖尿病 非胰岛素依赖型 冠心病 微量白蛋白尿 

分 类 号：R587.102[医药卫生—内分泌] R541.402[医药卫生—内科学]