子囊菌的分离、分布及其生理活性的研究  

Isolation,Distribution and Physiological Activity of Ascomycete

作　　者：刘梅[1] 张鹏[1] 崔晓兰[2] 丁彦博[2] 郑智慧[2] 董悦生[2] 张华[2] 

机构地区：[1]北京化工大学生命科学与技术学院,北京100029 [2]华北制药集团新药研究开发有限责任公司微生物药物国家研究工程中心,河北石家庄050015

出　　处：《河北大学学报（自然科学版）》2006年第1期58-60,共3页Journal of Hebei University(Natural Science Edition)

基　　金：国家科技部创新药物筛选技术平台研究资助项目(2002AA2AZ343D)

摘　　要：采用子囊菌的选择性分离方法分离土壤样品,分离得到的子囊菌比例为常规稀释法的2.8倍;对子囊菌在河北、广西、云南等地的分布情况进行初步统计,云南省的子囊菌资源较丰富;应用多个药物筛选模型对分离得到的真菌进行筛选,在Caspase-3模型中,子囊菌的活性菌株是其他真菌的2.3倍.The number of Ascomycote isolated from soil samples by the selective method was 2.8 times as that by the conventional method. The distribution of Ascomycote in Hebei, Guangxi and Yunnan provinces was investigated. The results showed that Ascomycote was much abundant in soil of Yunnan province. The metabolites of isolated fungi were then screened by drug screening models and the hit rate of metabolites produced by Ascomycote was 2.3 times as that of other fungi in the Caspase-3 inhibitor screening.

关 键 词：子囊菌 分离 分布 生理活性 CASPASE-3 

分 类 号：Q93[生物学—微生物学]