Associations between y-glutamyl transferase, metabolic abnormalities and inflammation in healthy subjects from a population-based cohort: A possible implication for oxidative stress  

作　　者：Simona Bo Roberto Gambino Marilena Durazzo Sabrina Guidi Elisa Tiozzo Federica Ghione Luigi Gentile Maurizio Cassader Gian Franco Pagano 

机构地区：[1]Department of Internal Medicine [2]Diabetic Clinic

出　　处：《World Journal of Gastroenterology》2005年第45期7109-7117,共9页世界胃肠病学杂志（英文版）

基　　金：Supported by a grant: "Progetto di Ricerca Sanitaria Finalizzata,Regione Piemonte, 2003"

摘　　要：AIM: To examine the relationships between γ -glutamyltransferase (GGT), alanine-aminotransferase (ALT),aspartate-aminotransferase (AST) and various metabolic parameters, C-reactive protein (CRP) and an oxidative stress marker (nitrotyrosine, NT) in subjects without any metabolic abnormalities from a population-based sample.METHODS: Two hundred and five subjects with normal body mass index (BMI), glucose tolerance, and without any metabolic abnormality were studied out of 1339subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti (north-western Italy).RESULTS: In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference,hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple confounders.In the same model, median NT levels are significantly associated with the increasing GGT tertile (β = 1.06;95%CI 0.67-1.45), but not with the AST and ALT tertiles.In a multiple regression model, after adjusting for age,sex, BMI, waist, smoking, and alcohol consumption, both NT (β = 0.05; 95%CI 0.02-0.08) and hs-CRP levels (β =0.09; 95%CI 0.03-0.15) are significantly associated with fasting glycemia.CONCLUSION: GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects.AIM： To examine the relationships between γ -glutamyltransferase （GGT）, alanine-aminotransferase （ALT）, aspartate-aminotransferase （AST） and various metabolic parameters, C-reactive protein （CRP） and an oxidative stress marker （nitrotyrosine, NT） in subjects without any metabolic abnormalities from a population-based sample. METHODS： Two hundred and five subjects with normal body mass index （BMI）, glucose tolerance, and without any metabolic abnormality were studied out of 1 339 subjects, without known liver diseases, alcohol abuse or use of hepatotoxic drugs, who are representative of the 45-64 aged population of Asti （north-western Italy）. RESULTS： In all patients metabolic parameters and hs-CRP levels linearly increase from the lowest to the highest ALT and GGT tertiles, while in subjects without metabolic abnormalities, there is a significant association between fasting glucose, uric acid, waist circumference, hs-CRP, triglyceride values, and GGT levels. In these subjects, male sex, higher hs-CRP and glucose levels are associated with GGT levels in a multiple regression model, after adjustments for multiple confounders. In the same model, median NT levels are significantly associated with the increasing GGT tertile （β = 1.06; 95% CI 0.67-1.45）, but not with the AST and ALT tertiles. In a multiple regression model, after adjusting for age, sex, BMI, waist, smoking, and alcohol consumption, both NT （β = 0.05; 95%CI 0.02-0.08） and hs-CRP levels （β = 0.09; 95%CI 0.03-0.15） are significantly associated withfasting glycemia. CONCLUSION： GGT, an easy, universally standardized and available measurement, could represent an early marker of sub-clinical inflammation and oxidative stress in otherwise healthy individuals. Prospective studies are needed to establish if GGT could predict future diabetes in these subjects.

关 键 词：Alanine aminotransferase Aspartate aminotransferase Body mass index C-reactive protein γ-Glutamyl transferase Metabolic syndrome NITROTYROSINE 

分 类 号：R589[医药卫生—内分泌]