正己烷接触对血清神经元特异烯醇化酶及髓鞘碱性蛋白的影响  

Study on serum NSE level and serum MBP level in the workers exposed to n-hexane

作　　者：苏胜华 刘新霞[2] 甘德秀[3] 邝海沙[3] 魏青[3] 许雷[3] 许发茂[3] 

机构地区：[1]广东省健康教育研究所,广东广州510230 [2]中山市疾病预防控制中心,528400 [3]中山大学公共卫生学院,广州510080

出　　处：《中国职业医学》2006年第1期22-23,26,共3页China Occupational Medicine

基　　金：美国中华医学会基金课题(编号:532409300)

摘　　要：目的研究正己烷接触对血清神经元特异烯醇化酶(NSE)及髓鞘碱性蛋白(MBP)的影响。方法分别对接触组37名及对照组49名工人应用酶联免疫吸附法测定其NSE及MBP的血清含量。结果接触组和对照组的血清NSE含量分别为(8.4±7.7)、(7.8±3.2)μg/L,接触组的血清NSE水平高于对照组(P<0.05);血清MBP含量分别为(1.59±0.54)、(0.94±0.27)μg/L,接触组明显高于对照组(P<0.05)。结论正己烷接触可导致血清NSE及MBP升高。Objective To study the effect of n-hexane exposure on serum level of neuron specific enolase （NSE） and the serum melin basic protein （MBP）. Methods 37 n-hexane exposed workers and 49 non-exposed ones from a factory in Zhongsban, Guangdong Province were selected in the study. Serum MBP and serum NSE levels were determined by ELISA. Results Serum NSE level in the exposed workers was （ 8.4 ± 7.7 ）μg/L, which was higher than that in the controls [ （7.8 ±3.2）μg/L, P 〈0. 05]. The serum MBP level in the exposed workers[ （ 1.59±0. 54）μg/L]was also higher than that in the controls [ （0. 94±0. 27）μg/L,P 〈0. 05]. Conclusion Exposure to n-hexane might induce the increase of serum NSE and MBP levels.

关 键 词：正己烷 神经元特异烯醇化酶 髓鞘碱性蛋白 

分 类 号：R135.1[医药卫生—劳动卫生]