煤工尘肺患者一氧化氮、丙二醛、超氧化物歧化酶的测定分析  

Detection and analysis on NO,MDA and SOD in coal workers with pneumoconiosis

作　　者：王娜[1] 姚武[1] 付鹏钰[1] 牛姬飞[1] 焦洁[1] 

机构地区：[1]郑州大学公共卫生学院劳动卫生与卫生毒理学教研室,河南郑州450052

出　　处：《中国职业医学》2006年第1期30-31,共2页China Occupational Medicine

摘　　要：目的探讨一氧化氮(NO)、丙二醛(MDA)和超氧化物歧化酶(SOD)在煤工尘肺发生发展中的意义。方法分别采用硝酸还原酶法、硫代巴比妥酸显色法、黄嘌呤氧化酶法测定50例煤工尘肺患者与50例健康对照血清NO、MDA的含量及SOD的活力。结果煤工尘肺患者血清中NO和MDA的含量分别为高于对照组,SOD活力低于对照组,差异均有统计学意义(P<0.05)。3指标相关性分析表明,煤工尘肺患者血清NO与SOD呈负相关关系(P<0.05),而NO与MDA、MDA与SOD之间均无相关关系(P>0.05);在健康对照组中,3指标均无相关关系(P>0.05)。结论煤工尘肺患者体内氧自由基反应异常、氧化/抗氧化状态失衡可能与尘肺的发生发展有关。Objective To study the significance of oxidative injury in the occurrence and development of pneumoconiosis in coal workers. Methods With the method of nitrate reductase, TBA, and xanthine oxidase, the content of NO, MDA and SOD in serum were detected in 50 patients suffering from coal worker＇ s pneumoconiosis and 50 healthy controls. Results The contents of NO and MDA in the pneumoconiosis patients were higher than those of the control, the content of SOD was lower than that of the control, and there were statistical significances between two groups （ P 〈 0. 05 ）. Conclusion There is abnormlty of oxyradical reaction and unblance between oxidation/antioxidation state in the patients with coal worker＇s pneumoconlosis, which may be related to the occurrence and development of coal workers＇ pneumoconiosis.

关 键 词：煤工尘肺 一氧化氮 丙二醛 超氧化物歧化酶 

分 类 号：R135.2[医药卫生—劳动卫生]