锌与基因表达的研究进展  

Effect of zinc on gene expression

作　　者：訾乃涛[1] 井明艳[1] 付亮剑 赵树盛 

机构地区：[1]浙江大学动物分子营养学教育部重点实验室,杭州市310029 [2]北京昕大洋科技发展有限公司 [3]浙江维丰生物科技有限公司,杭州市310029

出　　处：《中国饲料》2006年第3期8-11,共4页China Feed

摘　　要：锌是机体所必需的一种微量元素,在细胞分化和生长中起着重要作用。细胞内的部分锌存在于细胞核内,在维持遗传稳定性和调控基因表达中起着重要作用。近年来,有关锌对基因表达的影响主要集中于转录水平,即锌通过影响转录因子(含有锌指域)的活性进而调控细胞增殖、分化及细胞死亡。本文就锌调控基因表达的相关方面作一综述。A significant portion of cellular zinc is found in the nucleus where it appears to be critically involved in maintaining genetic stability and the process of gene expression.With regard to gene expression zinc functions mechanistically at several levels,recent interest has focused especially on the involvement of zinc in DNA transcription through the activity of transcription factors which contain specific zinc-finger regions which bind to DNA and in conjunction with other families of transcription factors,control cell proliferation,differentiation and cell death.Zinc and gene expression were reviewed in this article.

关 键 词：辞 遗传稳定性 基因表达 金属硫蛋白 DNA修复与细胞凋亡 

分 类 号：S811.1[农业科学—畜牧学]