黄花倒水莲降血脂活性成分研究  

Study on the Antihyperlipidemia Effective Constituent of Polygala fallax Hemsl.

作　　者：徐康平[1] 黄伟[1] 谭健兵[1] 周应军[1] 李福双[1] 黄朝辉[1] 刘保川[1] 谭桂山[1] 

机构地区：[1]中南大学药学院药物化学系,湖南长沙410013

出　　处：《中药材》2006年第1期16-19,共4页Journal of Chinese Medicinal Materials

基　　金：湖南省科技厅资助项目(20001011-5)

摘　　要：从黄花倒水莲Polygala fallaxHem sl.根的降血脂有效部位中分离得到四个皂苷类化合物,分别鉴定为3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl presenegen in 28-O-β-D-xylopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)--βD-fucopyransoyl ester(Ⅰ)、3-O--βD-glucopyranosyl-(1→2)--βD-glucopyranosyl presenegen in 28-O-β-D-xy-lopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→2)-(3-O-acetyl)-β-D-fucopyranosyl ester(Ⅱ)、3-O-β-D-glucopyranosyl-(1→2)-β-D-glucopyranosyl presenegen in 28-O-β-D-xylopyranosyl-(1→4)--αL-rhamnopyranosyl-(1→2)-(4-O-acetyl)-β-D-fucopyranosyl ester(Ⅲ)和3-O-β-D-glucopyranosyl-(1→2)--βD-glucopyranosyl presenegen in 28-O-β-D-xylopyrano-syl-(1→4)-α-L-rhamnopyranosyl-(1→2)-(3,4-d iacetyl)--βD-fucopyranosyl ester(Ⅳ)。Objective： To study the antihyperlipidemia effective constituent of PolygalafaUax Hemsl. Method： Column chromatographic techniques were employed for isolation and purification of chemical constituents of the plant and the structures were elucidated by IR, NMR and MS spectroscopy. Result： Four triterpenoid saponins were isolated and determined as 3-O-β -D-glueopyranosyl- （ 1→2 ） -β -D-glueopyranosyl presenegenin 28-O-β - D-xylopyranosyl- （ 1 →4 ） -α -L-rhamnopyranosyl-（1→2） -β-D-fueopyransoyl ester （ Ⅰ ）, 3-O-β-D-glucopyranosyl - （ 1 →2 ） -β-D-glucopyranosyl presenegenin 28-O-β-D-xy-lopyranosyl-（ 1 →4 ） -α-L-rhamnopyranosyl-（ 1 →2 ） -（3-O-acetyl） -β-D-fueopyranosyl ester（ II ）, 3-O-β-D-glucopyranosyl -（1 →2 ）-β-D-glucopyranosyl presenegenin 28-O-β-D-xylopyranosyl-（ 1 → ）-α-L-rhamnopyranosyl- （ 1 →2 ）-（ 4-O-acetyl ）-β-D-fueopyranosyl ester （Ⅲ） and 3-O-β-D-glucopyranosyl-（1→2）-β-D-glueopyranosyl presenegenin 28-O-β-D-xylopyranosyl- （ 1→4） -α -L-rhamnopyranosyl- （ 1→2 ） - （3,4-diacetyl） -β-D-fueopyranosyl ester （ Ⅳ ） . Conclusions： The effective constituents of PolygalafaUax Hemsl. reduced blood lipid especially plasma TG markedly. The authors have studied the chemical constituents of effective constituent systematically for the first time.

关 键 词：黄花倒水莲 皂苷 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]