非甾体抗炎药ZLR-8喷雾干燥乳剂的处方研究  

Formulation study of spray-dried emulsion of ZLR-8:a nitric oxide-releasing anti-inflammatory drug

作　　者：郑增娟[1] 张建军[1] 周建平[1] 张奕华[2] 

机构地区：[1]中国药科大学药剂学教研室 [2]中国药科大学新药研究中心,南京210009

出　　处：《中国药科大学学报》2006年第1期33-36,共4页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助资助项目(No.30271491);江苏省自然科学基金资助项目(No.BK2002119)~~

摘　　要：目的:对极难溶性的氮氧供体型非甾体抗炎药ZLR-8喷雾干燥乳剂进行处方研究。方法:根据ZLR-8的溶解性筛选油及非水溶剂;根据乳化性能及喷雾干燥的可操作性筛选羟丙甲纤维素(HPMC)的规格、浓度和其他适宜的固体载体;采用喷雾干燥法制备ZLR-8干乳剂。结果:以Labrafac CC作油相,PEG 400作非水溶剂,联用9%HPMC(3 mPa.s)和麦芽糖糊精作固体载体,可制成稳定的喷雾干燥乳剂。结论:确定了氮氧供体型非甾体抗炎药ZLR-8喷雾干燥乳剂的处方。Aim：To formulate the spray-dried emulsion of ZLR-8, a new NO-donor nonsteroidal anti-inflammatory drug with poor absorption and sparingly aqueous solubility. Methods： Oils and non-aqueous solvents were screened by determining the solubilities of ZLR-8. ZLR-8 dry emulsions were prepared by spray drying liquid o/w-emulsions in a laboratory spray dryer. The types and concentrations of HPMC and other solid carriers were screened by the emulsification characteristics and the spray-drying maneuverability. Results：The optimized spray-dried emulsions were composed of Labrafac CC oil as lipid phase, PEG 400 as non-aqueous solvent and a combination of 9% HPMC （3 mPa·s）with maltdextrin as solid carriers. Conclusion：ZLR-8 spray-dried emulsion could be formulated.

关 键 词：非甾体抗炎药 氮氧供体型 ZLR-8 喷雾干燥乳刑 处方研究 

分 类 号：R94[医药卫生—药剂学]