实验兔心肌梗死模型的建立与其在心肌造影超声心动图中的应用价值  

Establishment and evaluation of experimental model of rabbits for myocardial contrast echocardiography

作　　者：张玖[1] 闫子兴[1] 乔英艳[1] 郝林娃[1] 卢芳[1] 李曙光[1] 

机构地区：[1]山西医科大学第二医院,030001

出　　处：《山西医药杂志》2006年第2期106-107,共2页Shanxi Medical Journal

基　　金：山西省卫生厅科研资助项目(99012)

摘　　要：目的建立用于心肌造影超声心动图的实验兔心肌梗死模型并探讨其应用价值。方法将20只健康中国家兔速眠新肌肉麻醉,不用气管插管和呼吸机,经胸骨左缘切口开胸暴露心脏,行超声检查,阻断冠状动脉前降支40 min,造成急性心肌缺血模型,之后再灌注1 h,于冠状动脉阻断前、阻断中及再灌注后不同时间经静脉注射造影剂进行心肌造影超声心动图研究。结果20只兔经静脉注射造影剂后获得满意心肌造影图像,14只兔完成了全部的实验。结论胸骨左缘切口开胸兔心肌梗死模型可以成功地进行心肌造影超声心动图研究。Objective To establish the experimental model of rabbits for myocardial contrast echocardiography （MCE） and evaluate its significance. Methods Twenty healthy Chinese rabbits were anesthetized by Sumianxin. The rabbit was not intubated and ventilated. The thoraeotomy was performed along the left sternum with pleura cavity integrity. The hearts were exposed for MCE. The proximal of the left arterial descending coronary artery （LAD） was occluded for 40 min, followed by 1 h reperfusion. The MCE through the intravenous injection of selfmade contrast agent was performed. Results Satisfactory imaging was acquired. Fourteen rabbits went through the whole experiment. Conclusion The left thoracotomy openchest model of rabbits can be used in the MCE.

关 键 词：动物模型 心肌梗塞 兔 超声心动描记术 心肌造影 

分 类 号：R542.22[医药卫生—心血管疾病]