肿瘤坏死因子-α、白介素-6和红细胞生成素与小儿慢性病贫血的相关性分析  

Exploration on the association between cytokines TNF-α、IL-6 、EPO and anemia of chronic diseases in children

作　　者：林雪峰[1] 王忠[1] 吴秀梅[2] 王晓岚[1] 朱小虎[1] 

机构地区：[1]常州市儿童医院,江苏常州213003 [2]常州市第二人民医院,江苏常州213003

出　　处：《中国实用儿科杂志》2006年第2期112-113,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的探讨小儿慢性病贫血(ACD)时外周血肿瘤坏死因子(TNF)α、白介素(IL)6与红细胞生成素(EPO)的变化及其在发病机制中的作用。方法2002年4月至2004年12月常州市儿童医院收治ACD患儿19例(ACD组),采用放射免疫分析方法测定患儿外周血清中TNFα、IL6、EPO水平;对照组为17例上呼吸道感染恢复期患儿。结果与对照组比较,ACD组患儿血清中TNFα、IL6均显著增高(P<0.05)。血清TNFα、IL6与血清铁蛋白质量浓度呈正相关。结论免疫及炎症反应所产生的细胞因子TNFα、IL6可能通过干扰铁代谢和抑制EPO生成、钝化对EPO的反应等途径介导了ACD的发生和发展过程。Objective To explore the role of TNF-α IL-6 and EPO in the pathogensis of anemia of chronic diseases （ ACD） in children. Methods The levels of serum TNF-α, IL-6 and EPO were determined by immunoassays in 19 ACD patients. Results The serum levels of TNF-α, IL-6 in ACD patients were significantly higher than those in the control group （ P 〈 0. 05 ）. There were a positive correlation between the serum levels of TNF-α or IL-6 and serum ferritin. Conclusion TNF-α, IL-6 resulting from immune and inflammatory reaction may play an important role in the development of ACD by intervening iron metabolism, inhibiting the generation of erythropoietin （ EPO ） and dulling the response of bone marrow to EPO.

关 键 词：慢性病贫血 肿瘤坏死因子-Α 白细胞介素-6 红细胞生成素 

分 类 号：R72[医药卫生—儿科]