HBV-Pre-C区段变异患者血清HBVDNA和前S1抗原的检测  

The detection of serum HBVDNA and Pre-S1 in patients with HBV precore mutant

作　　者：张海谱[1] 李仕英[1] 谢晓民[1] 张丽娜[1] 

机构地区：[1]白求恩国际和平医院,河北石家庄050082

出　　处：《中原医刊》2006年第4期1-2,共2页Central Plains Medical Journal

摘　　要：目的探讨HBVDNA和前S1抗原(Pre-S1)在HBV-Pre-C区段变异株感染者中的临床应用价值。方法102份乙型肝炎患者血清标本,按HBeAg阳性、HBeAg阴性且HBV-Pre-C区段(nt1896)变异阳性和HBeAg阴性且HBV-Pre-C区段(nt1896)变异阴性分为三组,分别对Pre-S1和HBVDNA进行检测分析。结果HBV-Pre-C区段变异阳性组Pre-S1和HBVDNA检测结果与HBeAg阳性组比较无统计学意义(P>0.05);HBV-Pre-C区段变异阴性组Pre-S1和HBVDNA与HBeAg阳性组比较差异有统计学意义(P<0.01)。结论Pre-S1与HBVDNA在评价HBV复制上有高度的一致性,在检测HBV-Pre-C区段变异患者时有相似的应用价值。Objective To explore the value of HBVDNA and Pre -S1 in patients with HBV precore mutant. Methods 102 serum samples of type B hepatitis, dividd in to three groups according to HBeAg positive, HBeAg negative and HBV - Pre - C segment mutation positive or negative, separately detected and analyzed the HBVDNA and Pre - S1. Results The HBVDNA and Pre - S1 results of group HBV - Pre - C segment mutation positive had no significant difference with HBeAg positive （ P 〉 0.05 ）, but group HBV - Pre - C segment mutation negative had significant difference with HBeAg positive（ P 〈 0.01 ）. Conclusions HBVD- NA and Pre -S1 have high consistency in evaluating HBV duplication, and have semblation applicable value in detecting HBV -Pre- C segment mutation.

关 键 词：前S1抗原 乙型肝炎病毒DNA 变异 

分 类 号：R446.6[医药卫生—诊断学] R450[医药卫生—临床医学]