右美沙芬对局灶脑缺血所致的c－fos蛋白表达的抑制作用  

Inhibitory effects of dextromethorphan on c fos protein expression during focal cerebral ischemia in rats 1

作　　者：包维丽[1] 陆世铎[1] 程介士[1] 张安中[1] 

机构地区：[1]上海医科大学医学神经生物学国家重点实验室

出　　处：《中国药理学报》1996年第5期418-420,共3页Acta Pharmacologica Sinica

摘　　要：右美沙芬对局灶脑缺血所致的ｃｆｏｓ蛋白表达的抑制作用包维丽，陆世铎，程介士，张安中（上海医科大学医学神经生物学国家重点实验室，上海２０００３２，中国）关键词脑缺血；原癌基因蛋白ｃｆｏｓ；免疫组织化学；右美沙芬目的：观察右美沙芬对局灶脑缺血所致的ｃ...IM: To study the effect of dextromethorphan (DM) in focal cerebral ischemia. METHODS: The c fos protein was detected immuno￣histochemically in the brain of rats after focal cerebral ischemia (induced by placing a nylon thread in the lumen of the internal carotid artery) with and without treatment with DM. RESULTS: Focal cerebral ischemia induced c fos protein expression outside the core territory of the middle cerebral artery (MCA) and neuronal damage in the core territory of the MCA. There was an evident expression of c fos protein in the ipsilateral regions outside the MCA territory (eg cingulate cortices, piriform cortices and entorhinal cortices), and in the contralateral regions of hippocampus after 4 h reperfusion following 1 h MCA occlusion. But morphological results showed severe edema and neuronal damage in the core territory and the ipsilateral hippocampus. DM blocked both the c fos protein induction and neuronal damage in all regions. CONCLUSION: DM reduced c fos protein expression and blocked the neuronal damage after focal cerebral ischemia.

关 键 词：脑缺血 原癌基因蛋白 C-FOS 右美沙芬 

分 类 号：R971[医药卫生—药品] R967[医药卫生—药学]