多培沙明对离体兔缺氧心功能的影响及其与非诺多泮和丙卡特罗效应的比较  

Effects of dopexamine on heart function of isolated hypoxic rabbit heart and in comparison with fenoldopam and procaterol 1

作　　者：秦富忠[1] 王文泽[1] 赵荣瑞[1] 

机构地区：[1]山西医学院生理教研室

出　　处：《中国药理学报》1996年第5期435-438,共4页Acta Pharmacologica Sinica

摘　　要：多培沙明对离体兔缺氧心功能的影响及其与非诺多泮和丙卡特罗效应的比较秦富忠，王文泽，赵荣瑞（山西医学院生理教研室，太原０３０００１，中国）关键词多巴胺激动剂；多培沙明；非诺多泮；丙卡特罗；左心室功能；冠脉循环；缺氧目的：研究多培沙明（Ｄｏｐ）对离体兔心...IM: To study the effects of dopexamine hydrochloride (Dop) on heart functions and coronary flow (CF) of normal and hypoxic isolated perfusing heart and compare the effects of Dop with those of fenoldopam hydrochloride (Fen) and procaterol hydrochloride (Pro). METHODS: The isolated rabbit normal and hypoxic hearts were perfused with Krebs Henseleit (K H) solution via aorta at 37±0 5 ℃. The drug were added into the K H solution. RESULTS: Dop increased the CF, left ventricular contractile function ( +d p / d t max etc) and heart rate (HR) in normal heart; Fen increased the heart function more potently, but increased the CF to a lesser degree than Dop did, whereas the effects of Pro was the least. In simple hypoxic group, at 30 min of perfusion, the +d p /d t max and CF decreased by 66±4 % and 48 1±1 0 %, respectively. Dop remarkably attenuated the decreases in both CF and heart function during hypoxia as it decreased the +d p /d t max by 32 0±2 4 % and CF by 28±3 %. Fen was less potent than Dop in attenuating the diminution of CF, while Pro was the least effective. CONCLUSION: Dop has a better prospect in the treatment of ischemic heart disease in view of its dual action of increasing CF and inotropism.

关 键 词：多培沙明 非诺多泮 左心室功能 冠脉循环 缺氧 

分 类 号：R972[医药卫生—药品] R969.4[医药卫生—药学]