戊巴比妥钠对豚鼠乳头状肌电活动和机械收缩的影响  

Effects of sodium pentobarbital on electric and mechanical activities of guinea pig papillary muscle

作　　者：张翼[1] 谷双振[1] 郝永昌[1] 宋立林[1] 郭书梅[1] 卢慎圭 

机构地区：[1]河北医科大学生理教研室

出　　处：《中国药理学报》1996年第5期439-441,共3页Acta Pharmacologica Sinica

摘　　要：戊巴比妥钠对豚鼠乳头状肌电活动和机械收缩的影响张翼，谷双振，郝永昌，宋立林，郭书梅，卢慎圭（河北医科大学生理教研室，石家庄０５００１７，中国）关键词戊巴比妥；电生理学；动作电位；乳头状肌；钾通道目的：研究戊巴比妥钠（ＳＰ）对豚鼠心室乳头状肌动作电位（...IM: To study the effects of sodium pentobarbital (SP) on the action potential (AP) and contraction of guinea pig papillary muscle. METHODS: Using conventional glass microelectrode and mechanical recording of myocardium contraction. RESULTS: SP (≥10 μmol·L -1 ) prolonged the AP duration (APD) and effective refractory period (ERP), while amplitude (APA) and V max of phase 0 showed no changes. The effects of SP were abolished by pretreatment with cromakalim, an agonist of ATP sensitive K + channel. The maximal isometric tension ( P max ) and velocity of tension development (d T /d t ) were decreased to 51 % and 48 % of control, respectively. The first postrest beat (B 1) and second postrest beat (B 2) were also depressed. CONCLUSION: SP affected the action potential by reducing activities of the K + channels and reduced the contraction of guinea pig myocardium.

关 键 词：戊巴比妥 电生理学 动作电位 乳头状肌 钾通道 

分 类 号：R972[医药卫生—药品] R964[医药卫生—药学]