O型孕妇血清IgG抗AB效价测定的临床意义  

Clinical significance of anti-AB titer of pregnant women with blood group O

作　　者：谢作听[1] 陈碧乐[1] 吴文鹤[2] 陶志华[1] 王春香[1] 

机构地区：[1]温州医学院附属第一医院输血科,浙江温州325000 [2]温州医学院检卫学院

出　　处：《中国实验诊断学》2006年第2期177-179,共3页Chinese Journal of Laboratory Diagnosis

摘　　要：目的对夫妻血型不合的O型孕妇进行血清IgG抗AB效价测定并初步探讨其临床意义。方法采用2-me裂解-37℃吸收-56℃释放-微柱凝胶法分别检测O型男性献血员血清和不同胎次孕妇的血清IgG抗AB效价。结果O型男性献血员血清IgG抗AB总阳性率为18.3%(11/60),且IgG抗A或抗B效价小于512者血清中均未检到IgG抗AB;孕妇组的总阳性率为52.8%(38/72),其中第一胎孕妇血清IgG抗AB阳性率为47.4%(18/38),非第一胎孕妇血清IgG抗AB阳性率为58.8%(20/34)。统计学结果表明,孕妇组与献血员组的IgG抗AB阳性率有显著性差异(P<0.01)。结论IgG抗AB与妊娠可能密切相关,胎母血型不合的妊娠(包括流产),可能会导致O型孕妇血清IgG抗AB效价升高,通过IgG抗AB效价的动态测定有望对新生儿溶血病或者胎儿血型进行预测。Objective To detect anti-AB（IgG） in sera of the pregnant women with blood group O whose husbunds＇ is not O, then to explore its clinical significances. Methods 60 cases male donors with blood group O and 72 cases pregant women with different pregnancy times were detected by micro-column gel test（MGT）. Results The positive rate of the male donets group were 18.3% （11/60）. What was necessarily metioned was the rates were zero when their anti-A（IgG） or anti-B（IgG） less than 512 in scra; It was 52.8% （38/72） in the pregnant women group（in which, first-time pregnancy group was 47.4%, non-fitst-time pregnancy group was 58.8% ）. Statistics results indicated there were significant difference between male donors group and the pregnant women group（P 〈 0.01）. ConcIuslon It was possible that there were relations between anti-AB（IgG） and pregnancy, and the latter（include abortion） could cause the former increase. There maybe were feasibilities to predict HDN or blood group for fetuses by dynamic detection of anti-AB（IgG）.

关 键 词：血型 抗体 

分 类 号：R446.6[医药卫生—诊断学]