乙型肝炎患儿细胞因子与HBV DNA及血清乙肝标志物的关系  

Relationship between Cytokines in children and HBV DNA in serum,hepatitis B virus markers.

作　　者：张雷家[1] 张金萍[2] 胡冰[3] 

机构地区：[1]绍兴文理学院医学院附属医院儿科,浙江绍兴312000 [2]绍兴文理学院医学院,浙江绍兴312000 [3]济宁市传染病医院,山东济宁272031

出　　处：《临床肝胆病杂志》2006年第1期27-28,共2页Journal of Clinical Hepatology

摘　　要：探讨小儿慢性乙型肝炎(CHB)细胞因子IL-12和INFγ与HBV DNA定量及HBVM的关系及意义。46例慢性乙型肝炎患儿和30例健康儿童均分别以ELISA法检测IL-12和IFNγ及HBVM,以荧光定量PCR法检测HBV DNA。HBeAg阴性组IL-12和IFNγ较HBeAg阳性组明显升高(P值均<0.05)。高病毒载量组IL-12和IFNγ水平均显著高于对照组(P值均<0.01)。慢性乙型肝炎患儿IL-12和IFNγ与HBeAg及HBV DNA水平密切相关。To investigate the serum levels of IL- 12,IFNγ, quantitative HBV DNA, HBVM, and their sense in children with chronic hepatis B （CHB）. The serum IL- 12, IFNγ and HBVM, HBV DNA of 46 CHB patients were measured by specific- EIJSA and PCR respectively 30 healthy children wen employed as the control. The serum levels of IL- 12, IFNγ in HBeAg negative CHB were higher than those in HBeAg positive CHB patients （ P 〈 0.05）. The serum levels of IL- 12, IFNγ of high virus load group were significantly higher than those in the control （ P 〈 0.01 ）. IL- 12 and IFNγ of children with CHB closely correlate with the HBeAg and HBV DNA.

关 键 词：小儿 乙型肝炎 慢性 细胞因子 乙肝病毒标志物 HBV DNA 

分 类 号：R725.1[医药卫生—儿科]