盐酸纳洛酮在急性重型颅脑损伤治疗中的应用研究  

Study on the Application of Naloxone Hydrochloride in the Treatment of Acute Craniocerebral Trauma

作　　者：王宝民[1] 王希柱[1] 胡艳玲[1] 石文建[1] 刘丽檀[1] 张茹[1] 

机构地区：[1]河北唐山市人民医院,唐山市063001

出　　处：《中国药房》2006年第4期288-289,共2页China Pharmacy

基　　金：河北省2002年医学科学研究重点课题(02231)

摘　　要：目的：探讨早期、大剂量盐酸纳洛酮在治疗急性重型颅脑损伤中的应用价值。方法：选择脑外伤后格拉斯哥（GCS）评分5分～8分患者79例，随机分为纳洛酮组41例与对照组38例．对照组给予脱水剂、糖皮质激素、抗菌药物及营养脑细胞药等常规治疗，纳洛酮组在对照组治疗基础上加用纳洛酮10d，观察2组治疗后GCS评分、血浆中β-内啡呔（β-EP）、呼吸循环指标及意识觉醒时间等变化．结果：纳洛酮组治疗后意识觉醒时间缩短、呼吸循环衰竭发生率低，β-EP下降程度及速度较对照组显著加快（P〈0．01或P〈0．05）。结论：盐酸纳洛酮在解除颅脑损伤中由内源性阿片肽引起的中枢及外周循环抑制有显著作用。OBJECTIVE： To assess the application value craniocerebral trauma.METHODS： 79 craniocerebral trauma of large dose of naloxone hydrochloride in treating early stage cases whose GCS scores were 5 to 8 scores were enrolled. 38 （control group） were randomly assigned to receive conventional therapy（dehydrating agent, glucocorticoid, antibacterials, nutritional brain cells, and so on）, and 41（naloxone group） to receive additional naloxone besides the conventional therapy as stated in the control group.Vartations on GCS scores,serumβ- endorphin（β- EP） level,indexes of respiration and circulation, and safe consciousness time of the 2 groups after treatment were observed.RESULTS： As compared with the control group, naloxone group had shorter safe consciousness time, lower incidences of respiration failure and circulatory failure, more and faster decrease of serumβ- EP level（P〈0.01 or P〈0.05） .CONCLUSION： Naloxone can significantly relieve endogenous opioid peptides- induced central and peripheral circulatory inhibitions in craniocerebral trauma,

关 键 词：盐酸纳洛酮 颅脑损伤 内源性阿片肽 

分 类 号：R971.2[医药卫生—药品]