茵陈蒿汤的发展及现代研究  

Evolution and Modern Research of Yinchenhao Decoction

作　　者：慕永平[1] 刘平[1] 王磊[1] 

机构地区：[1]上海中医药大学肝病研究所,上海201203

出　　处：《中国实验方剂学杂志》2006年第2期67-71,共5页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：上海市自然科学基金重点项目(NO:02JC14024)

摘　　要：综述了茵陈蒿汤的发展及研究现状,自仲景以来,历代将茵陈蒿汤化载用于治疗各类黄疸性疾病,现代研究表明,茵陈蒿汤不仅具有促进胆红素代谢的作用,还具有抗肝损伤,抑制肝细胞凋亡、抑制星状细胞活化及胶原合成等作用,其作用的物质基础主要为6,7-二甲基香豆素、都桷子素及大黄素等,并进一步明确了一些有效组分的作用靶点。Evolution and modem research of Yinchenhao Decoction were reviewed in this article. Yinchenhao Decoction had been modified to treat diseases with jaundice since the times of Zhang Zhong-jing in East Han dynasty. Modem research had validated the following pharmacologic effects of this herbal recipe as promoting bilirubin metabolism, auti-hepatic injury, inhibiting apoptosis of hepatocytes and collagen synthesis and inactivating hepatic stellate ceils. The substance basis for above effects involved 6,7-dimethylescutin, genipin and emodin, etc. In addition, several potential targets of these ingredients had also been verified.

关 键 词：茵陈蒿汤 方剂 肝损伤 胆汁瘀积 

分 类 号：R285.5[医药卫生—中药学]