血竭α-葡萄糖苷酶抑制剂活性与金属元素含量的多元分析  

Multianalysis between Dragon's Blood α-Glucosidase Inhibitor's Ability and Metals Concentration

作　　者：傅晓云[1] 吕敬慈[1] 雍克岚[2] 刘培培[2] 

机构地区：[1]上海大学理学院,上海200444 [2]上海大学生命科学学院,上海200444

出　　处：《上海大学学报（自然科学版）》2006年第1期66-68,共3页Journal of Shanghai University:Natural Science Edition

基　　金：上海市科技发展基金资助项目(02DZ9118)

摘　　要：采用统计分析软件SPSS12.0,对血竭α-葡萄糖苷酶抑制剂中铁、锰、铜、钙、镁5种金属元素含量与其活性进行多元逐步回归分析,建立了多元线性回归模型:[ID50]=-0.522+0.013[Ca]+0.234[Mn](R=0.975,P<0.05),筛选出2个对α-葡萄糖苷酶抑制剂活性具有显著影响的元素钙和锰;并对模型进行实验验证,为血竭α-葡萄糖苷酶抑制剂的筛选提供参考.Using statistic software SPSS12.0, relationship between Dragon＇s blood α-glucosidase inhibitor＇s ability and concentration of metals including iron, manganese, copper, calcium and magnesium were analyzed by multiple stepwise regression. The regression equation was established： [ ID50] = -0.522 ＋ 0.013 [Ca] ＋ 0.234[Mn] （R = 0.975, P 〈 0.05）, basing which calcium and manganese were considered as those elements affect the ability significantly. The equation was validated by experiment. It would be reference on selecting Dragon＇s blood α-glucosidase inhibitor.

关 键 词：血竭 Α-葡萄糖苷酶抑制剂 金属元素 多元逐步同归 

分 类 号：O652.9[理学—分析化学]