小儿急性阑尾炎手术前后sICAM-1、IL-8和TNFa的变化及其临床意义  

Serum sICAM-1, IL-8 and TNFα in children with acute appendicitis

作　　者：王建峰[1] 景东[2] 石正峰[2] 席红卫[2] 崔彦北[2] 陈博渊[2] 

机构地区：[1]山西医科大学儿科系,太原030013 [2]山西省儿童医院外科

出　　处：《中华小儿外科杂志》2006年第1期23-25,共3页Chinese Journal of Pediatric Surgery

基　　金：山西省自然科学基金资助(项目号:011041)

摘　　要：目的探讨急性阑尾炎患儿血清可溶性细胞间粘附分子-1(sICAM-1)、白细胞介素-8(IL-8)和肿瘤坏死因子-a(TNFa)的变化及临床意义。方法应用酶联免疫吸附测定法检测70例急性阑尾炎患儿不同时间(术前、术后7d)血清中sICAM-1、IL-8和TNFa的含量水平。结果各组术前血清sICAM-1、IL-8、TNFa的水平明显高于对照组(P<0.01);化脓性、坏疽穿孔性阑尾炎组血清sICAM-1与IL-8、TNFa变化呈正相关(P<0.05);单纯组外周血白细胞(WBC)与sICAM-1呈正相关(P<0.05);8例并发症血清sICAM-1与IL-8、TNFa升高明显。结论血清sICAM-1、IL-8和TNFa在小儿急性阑尾炎的发病中起着重要的作用,检测其变化对小儿急性阑尾炎的诊断、病程监测和预后估计具有一定的临床价值。Objective To explore the clinical significance of serum sICAM-1, IL-8, TNFa in children with acute appendicitis before and after operation. Methods The levels of serum sICAM-1, IL-8, TNFa were detected by ELISA in 70 children with the acute appendicitis before and after operation. Same indexes were also measured in control group. Results The levels of serum sICAM-1, IL-8 and TNFa in the children with acute appendicitis were significantly higher than those in control group. There was a positive correlation between the sICAM-1 and IL-8 or TNFa in the acute phlegmonous and gangrenous appendicitis. The serum level of sICAM-1 in children with catarrhal appendicitis was closely related with the count of white blood cells. Moreover, higher serum sICAM-1, IL-8 and TNFa was noted in 8 cases with postoperative complications. Conclusions Detection of serum sICAM-1, IL- 8 and TNFa may be useful for diagnosis and surveillance of the appendicitis in children.

关 键 词：阑尾炎 胞间粘附分子 白细胞介素8 肿瘤坏死因子A 

分 类 号：R726.5[医药卫生—儿科]