阿苯达唑和奥芬达唑对体外培养猪囊尾蚴能量代谢变化的影响  

Influences on Energy Metabolism of C.cellulosae During In vitro Development with Albendazole and Oxfendazole

作　　者：高学军[1] 李艳飞[1] 李庆章[1] 

机构地区：[1]东北农业大学动物医学院,黑龙江哈尔滨150030

出　　处：《中国兽医学报》2006年第1期71-73,共3页Chinese Journal of Veterinary Science

基　　金：国家自然科学基金资助项目(30371081)

摘　　要：测定了在阿苯达唑和奥芬达唑作用下体外培养猪囊尾蚴磷酸烯醇式丙酮酸羧激酶(PEPCK)、丙酮酸激酶(PK)、延胡索酸还原酶(FR)、苹果酸酶(ME)活性的变化及葡萄糖(GLC)、乳酸(LAC)含量的变化。结果表明,2种药物作用均可在体外作用条件下显著改变未成熟期及成熟期猪囊尾蚴的能量代谢。提示,苯并咪唑氨基甲酸酯类药物的作用机理可能是通过干扰虫体能量代谢,阻断能量的产生,导致虫体死亡。The activity of phosphoenolpyruvate carboxykinase, pyruvate kinase, fumarate reductase, malate dehydrogenase and the content of glucose, lactate in Cysticercus cellulosae during in vitro development with drugs were tested. The result showed that both albendazole and oxfendazole could have significant influences on energy metabolism of C. cellulosae during in vitro development. The results suggested that the benzimidazol carbamate drugs probably interfere the course of energy metabolism and lead to exhaustion of energy and death of cysticerci.

关 键 词：阿苯达唑 奥芬达唑 猪囊尾蚴 能量代谢 

分 类 号：S859.7[农业科学—临床兽医学]